Evidence for an ER to Golgi to chloroplast protein transport pathway
Evidence for an ER to Golgi to chloroplast protein transport pathway
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DOI：
10.1016/j.tcb.2006.06.003
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发表时间：
2006-08-01
影响因子：
19
通讯作者：
Theg, Steven M.
中科院分区：
文献类型：
--
作者：
Radhamony, Resmi N.;Theg, Steven M.
叶绿体蛋白质的输入一般认为是通过前体蛋白与质体被膜中的Toc和Tic运输装置的相互作用在后期发生的。存在于易位蛋白上的可切割的N-末端转运肽被认为是必需的并且足以用于靶向。这一想法最近受到挑战时，叶绿体蛋白质组的分析显示，许多蛋白质没有预测的转运肽。最近的一项研究表明，存在一种新的叶绿体靶向途径，开始与蛋白质进入内质网，并涉及高尔基体。
Chloroplast protein import is generally believed to occur posttranslationally through the interaction of a precursor protein with the Toc and Tic transport apparatus in the plastid envelope membranes. The cleavable N-terminal transit peptide present on translocated proteins has been considered to be essential and sufficient for targeting. This idea was recently challenged when an analysis of the chloroplast proteome revealed many proteins without a predicted transit peptide. A recent study demonstrates the existence of a novel chloroplast targeting pathway, starting with protein entry into the endoplasmic reticulum and involving the Golgi apparatus.