A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.
A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.
复制标题
从马达加斯加螳螂 (Mantella) 蛙的皮肤提取物中分离出的生物碱 235C 的修订结构。
DOI：
10.1021/np058089f
复制
发表时间：
2005
影响因子：
5.1
通讯作者：
Daly,JohnW
中科院分区：
文献类型：
--
作者：
Andriamaharavo,NRabe;Andriantsiferana,Marta;Stevenson,PaulA;O'mahony,Gavin;Yeh,HermanJC;Kaneko,Tetsuo;Garraffo,HMartin;Spande,ThomasF;Daly,JohnW
曼氏蛙属（Mantella genus）是食源性节肢动物生物碱的丰富来源。两种青蛙，栖息在沼泽森林，含有一组独特的生物碱，以前提出的，仅基于GC-MS和GC-FTIR数据，代表homopumiliotoxins的类似物。这一组的主要生物碱，生物碱235 C（2），现在已经分离出足够的数量（约。0.3 mg）以允许通过NMR分析确定结构。经结构鉴定，该化合物为7，8-二硫-8-去甲基海蛞蝓毒素。本文比较了235 C（2）和一种合成的脱氢高乌螺毒素（1）的质谱、红外光谱和1H NMR光谱，最初提出的235 C的结构是错误的。
Madagascan frogs of the mantellid genusMantellahave been a rich source of alkaloids derived from dietary arthropods. Two species of frogs, inhabiting swamp forest, contain a unique set of alkaloids, previously proposed, based only on GC-MS and GC-FTIR data, to represent dehydro analogues of the homopumiliotoxins. The major alkaloid of this set, alkaloid235C(2), now has been isolated in sufficient quantities (ca. 0.3 mg) to allow determination of the structure by NMR analysis. The structure of alkaloid235Cproved to be a 7,8-dehydro-8-desmethylpumiliotoxin. A comparison is presented between the mass, infrared, and1H NMR spectra of235C(2) and a synthetic dehydrohomopumiliotoxin (1), initially proposed incorrectly as the structure for235C.