Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure
Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure
复制标题
DOI：
10.1016/j.dcn.2018.02.008
复制
发表时间：
2018-04-01
影响因子：
4.7
通讯作者：
Wozniak, Jeffrey R.
中科院分区：
文献类型：
--
作者：
Hendrickson, Timothy J.;Mueller, Bryon A.;Wozniak, Jeffrey R.
目的：产前酒精暴露(PAE)的皮质异常包括脑回(LGI)、厚度(CT)、体积(CV)和表面积(CS)。这项研究提供了PAE皮质发育文献的纵向和发展背景。实验设计：来自四个FASD协作倡议(CIFASD)站点的58名PAE儿童和52名对照儿童，注册时年龄6-17岁。参与者接受了与PAE相关的身体异常和畸形面部特征的正式评估。MRI数据是在四个地点的三个平台(西门子、通用电气和飞利浦)上收集的。扫描间隔两年进行。检查LGI、CT、CS和CV的变化。主要观察：在LGI、CT和CV中发现了几个显著的地区性线性和二次交互作用效应，表明PAE的非典型发展轨迹。皮质测量与智商之间没有明显的相关性。结论：在PAE患者中，CT、CV和LGI在纵向上存在区域差异。这些发现代表了对发展轨迹的重要见解，并可能对在这一人群中进行评估和干预的时机产生影响。值得注意的是，皮质指标与智商没有相关性，这表明可能需要探索认知发展的更具体方面，以提供进一步的背景。
Objectives: Cortical abnormalities in prenatal alcohol exposure (PAE) are known, including in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides longitudinal and developmental context to the PAE cortical development literature.Experimental design: Included: 58 children with PAE and 52 controls, ages 6-17 at enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants underwent a formal evaluation of physical anomalies and dysmorphic facial features associated with PAE. MRI data were collected on three platforms (Siemens, GE, and Philips) at four sites. Scans were spaced two years apart. Change in LGI, CT, CS, and CV were examined.Principal observations: Several significant regional age-by-diagnosis linear and quadratic interaction effects in LGI, CT, and CV were found, indicating atypical developmental trajectories in PAE. No significant correlations were observed between cortical measures and IQ.Conclusions: Regional differences were seen longitudinally in CT, CV, and LGI in those with PAE. The findings represent important insights into developmental trajectories and may have implications for the timing of assessments and interventions in this population. It is noteworthy that cortical metrics did not correlate with IQ, suggesting that more specific aspects of cognitive development may need to be explored to provide further context.