Intraspecific scaling laws are preserved in ventricular hypertrophy but not in heart failure
Intraspecific scaling laws are preserved in ventricular hypertrophy but not in heart failure
复制标题
种内标度法则在心室肥厚中保留，但在心力衰竭中不保留。
DOI：
10.1152/ajpheart.00084.2016
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发表时间：
2016-11-01
影响因子：
4.8
通讯作者：
Kassab, Ghassan S.
中科院分区：
文献类型：
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作者：
Gong, Yanjun;Feng, Yundi;Kassab, Ghassan S.
了解代偿性（如左、右心室肥厚、LVH和RVH）和失代偿性血管重构（如充血性心力衰竭、CHF）中冠状动脉树的结构-功能分级具有重要的科学意义和临床意义。本研究假设血管树的种内缩放幂定律在肥厚性心脏中保留，而在CHF猪心脏中不保留。为了验证这一假设，我们对中度LVH、重度RVH和CHF的冠状动脉树的形态和血流动力学进行了尺度分析，并与年龄匹配的对照心脏进行了比较。对照组心脏的体积-直径、长度-体积和流量-直径幂律的标度指数与理论预测一致（分别为3、7/9和7/3），LVH和RVH心脏的标度指数保持不变。正常生长期间，随着体重的增加，鳞片指数也保持不变。CHF使心外膜动脉树的容积-直径和流量-直径标度指数分别为4.25±1.50和3.15±1.49。本研究验证了标度定律在诊断CHF心脏血管结构和功能方面的预测效用，以确定代偿性和失代偿性重构之间的界限。
It is scientifically and clinically important to understand the structure-function scaling of coronary arterial trees in compensatory (e.g., left and right ventricular hypertrophy, LVH and RVH) and decompensatory vascular remodeling (e.g., congestive heart failure, CHF). This study hypothesizes that intraspecific scaling power laws of vascular trees are preserved in hypertrophic hearts but not in CHF swine hearts. To test the hypothesis, we carried out the scaling analysis based on morphometry and hemodynamics of coronary arterial trees in moderate LVH, severe RVH, and CHF compared with age-matched respective control hearts. The scaling exponents of volume-diameter, length-volume, and flow-diameter power laws in control hearts were consistent with the theoretical predictions (i.e., 3, 7/9, and 7/3, respectively), which remained unchanged in LVH and RVH hearts. The scaling exponents were also preserved with an increase of body weight during normal growth of control animals. In contrast, CHF increased the exponents of volume-diameter and flow-diameter scaling laws to 4.25 ± 1.50 and 3.15 ± 1.49, respectively, in the epicardial arterial trees. This study validates the predictive utility of the scaling laws to diagnose vascular structure and function in CHF hearts to identify the borderline between compensatory and decompensatory remodeling.