The changing epidemiology of invasive Candidiasis - Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy
The changing epidemiology of invasive Candidiasis - Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy
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DOI：
10.1002/cncr.23466
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发表时间：
2008-06-01
期刊：
影响因子：
6.2
通讯作者：
Raad, Issam
中科院分区：
文献类型：
--
作者：
Hachem, Ray;Hanna, Hend;Raad, Issam
背景。本回顾性研究的目的是比较血液系统恶性肿瘤（HM）与实体瘤（ST）患者念珠菌血症的流行病学及其危险因素。方法。对 1993 年至 2003 年在作者所在机构患有念珠菌血症的所有癌症患者的医疗和电子记录进行了人口统计数据和临床信息的审查，包括预防性氟康唑的使用、感染性念珠菌种类以及念珠菌血症的来源（导管相关与其他明显来源）。 结果。对六百三十五名念珠菌血症患者进行了分析。光滑念珠菌和克柔念珠菌分别是 31% 和 24% HM 患者以及 18% 和 2% ST 患者念珠菌血症的主要原因（P
BACKGROUND. The objective of the current retrospective study was to compare the epidemiology of candidemia and its risk factors in patients who had hematologic malignancies(HM) with those in patients who had solid tumors (ST).METHODS. The medical and electronic records of all patients with cancer who had candidemia at the authors' institution from 1993 to 2003 were reviewed for demographic data and clinical information, including the use of prophylactic fluconazole, the infecting Candida species, and the source of candidemia (catheter-related vs other apparent sources).RESULTS. Six hundred thirty-five patients with candidemia were analyzed. C. glabrata and C. krusei were the leading causes of candidemia in 31% and 24% of patients with HM, respectively, and in 18% and 2% of patients with ST, respectively (P