Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
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DOI：
10.1001/archopht.121.12.1762
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发表时间：
2003-12-01
影响因子：
--
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
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作者：
Kang, JH;Pasquale, LR;Hankinson, SE
目的：探讨吸烟与原发性开角型青光眼（POAG）的关系。方法：分别于1980年和1986年至1996年对女护士和男卫生专业人员进行前瞻性随访。参与者至少40岁，在基线时没有诊断出青光眼，并报告在随访期间由眼科医生或验光师检查。吸烟史和其他POAG危险因素每两年更新一次问卷。共确定了450例POAG事件。进行了特定队列的比例风险分析和跨队列的汇总分析。结果：在控制了POAG的潜在危险因素（包括年龄、高血压和非裔美国人血统）后，当前吸烟者（相对危险度为0.85,95%可信区间为0.62-1.18）和过去吸烟者（相对危险度为0.91,95%可信区间为0.63-1.32）的POAG风险均不高于从不吸烟者。重度吸烟不会增加POAG的风险。吸烟包年与POAG存在适度的负相关关系：吸烟包年≥30的人POAG的风险降低22%（相对风险0.78；95%可信区间0.55-1.11；P为线性趋势）。（06）比那些从不吸烟的人。结论：吸烟不是POAG的重要危险因素。
Objective: To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG).Methods: Female nurses and male health professionals were prospectively followed up from 1980 and 1986, respectively, to 1996. Participants were at least 40 years old, were free of diagnosed glaucoma at baseline, and reported being examined by an ophthalmologist or optometrist during follow-up. Smoking history and other POAG risk factors were updated with biennial questionnaires. A total of 450 incident cases of POAG were identified. Both cohort-specific proportional hazards analyses and analyses pooled across cohorts were conducted.Results: After controlling for potential risk factors of POAG, including age, hypertension, and African American heritage, neither current smokers (relative risk, 0.85; 95% confidence interval, 0.62-1.18) nor past smokers (relative risk, 0.91; 95% confidence interval, 0.63-1.32) were at greater risk for POAG than those who had never smoked. Heavier smoking did not increase the risk of POAG. A modest inverse association was observed with pack-years of smoking: those with 30 or more pack-years had a 22% reduced risk of POAG (relative risk, 0.78; 95% confidence interval, 0.55-1.11; P for linear trend, .06) than those who had never smoked.Conclusion: Cigarette smoking is not an important risk factor for POAG.