Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules
Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules
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DOI：
10.1038/modpathol.2008.120
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发表时间：
2008-10-01
期刊：
影响因子：
7.5
通讯作者：
Kameya, Toru
中科院分区：
文献类型：
--
作者：
Kusafuka, Kimihide;Muramatsu, Koji;Kameya, Toru
乳腺基质性癌是化生性癌中一种公认的实体，其组织学特征是粘液软骨样基质形成，非常罕见。我们在这里描述四个额外的情况下，基质生产癌的乳腺癌。所有产生基质的癌都表现为巢状、片状和索状的肿瘤细胞生长，伴细胞浸润，此外，粘液样或粘液透明质间质内也有散在的癌细胞。4例中有3例在肿瘤中心显示无细胞或少细胞基质丰富区。免疫组化结果显示，所有病例的癌细胞均为细胞角蛋白和上皮膜抗原阳性，sox 9和p63部分阳性。聚集蛋白聚糖和II型胶原，这是软骨特异性基质分子，沉积在所有病例的基质中。所有病例的间质上也沉积有I型和IV型胶原。这些研究结果表明，虽然乳腺基质癌的癌细胞是上皮细胞，但它们转分化为软骨细胞样细胞并产生软骨特异性基质分子，这是诊断基质癌的有用标志物。
Matrix-producing carcinoma of the breast is a well-established entity in the group of metaplastic carcinoma, which is histologically characterized by myxochondroid matrix formation and is extremely rare. We describe here four additional cases of matrix-producing carcinoma of the breast. All cases of matrix-producing carcinoma show nest-like, sheet-like, and cord-like growth of tumor cells with cellular atypia, in addition to scattered cancer cells within myxoid or myxohyalinous stroma. Three of four cases showed an acellular or oligocellular matrix-rich zone in the center of the tumor. Immunohistochemically, cancer cells of all cases were positive for cytokeratins and epithelial membrane antigens and partially positive for sox9 and p63. Aggrecan and type II collagen, which are cartilage-specific matrix molecules, were deposited in the stroma of all cases. Type I and type IV collagens were also deposited on the stroma of all cases. These findings suggest that, although cancer cells of matrix-producing carcinoma of the breast are epithelial, they transdifferentiate to chondrocyte-like cells and produce cartilage-specific matrix molecules, which are useful markers for diagnosing matrix-producing carcinoma.