FMD virus isolates: The candidate strains for polyvalent vaccine development in Ethiopia
FMD virus isolates: The candidate strains for polyvalent vaccine development in Ethiopia
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DOI：
10.1016/j.actatropica.2013.02.005
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发表时间：
2013-06-01
期刊：
影响因子：
2.7
通讯作者：
Asmare, K.
中科院分区：
文献类型：
--
作者：
Ayelet, G.;Soressa, M.;Asmare, K.
对埃塞俄比亚口蹄疫病毒进行了研究，目的是选择合适的疫苗株来控制口蹄疫。采用二维病毒中和试验测定候选疫苗株与田间分离株的抗原关系“r”值。从牛和猪中分离到0型口蹄疫病毒21株，A型7株，SAT 2型8株。在试验中，每种血清型的几个分离株被鉴定为候选疫苗（O-ETH/38/2005、O-ETH/58/2008、A-ETH/7/2008、A-ETH/6/2000、SAT 2-ETH/76/2009和SAT 2-ETH/64/2009）。结果显示，所有候选疫苗均与研究血清型人群中其自身血清型具有较高的抗原相似性，高于平均“r”值，但一种血清型A田间分离株A-ETH/13/1981除外，其“r”值= 0.14和0.25）显著低于最低要求。总体而言，结果表明这些候选疫苗株可用于该国的多价疫苗生产。(C)2013爱思唯尔有限公司版权所有。
The study was conducted on foot-and-mouth disease (FMD) viruses with the aim of selecting appropriate vaccinal strain to control of FMD in Ethiopia. The study was conducted in two-dimensional virus neutralization assay to determine the antigenic relationship 'r' value between the candidate vaccine strains and field isolates. A total of 21 serotype 0,7 serotype A, and 8 serotype SAT 2 FMD viruses, which were isolated from cattle and swine. A couple of isolates from each serotype were identified as vaccine candidates in the trial (O-ETH/38/2005, O-ETH/58/2008, A-ETH/7/2008, A-ETH/6/2000, SAT2-ETH/76/2009 and SAT2-ETH/64/2009). The finding revealed all the vaccine candidate depicted high antigenic similarity, above the mean "r" value, to their own serotypes in the studied serotype population except for one serotype A field isolate, A-ETH/13/1981, with "r" value = 0.14 and 0.25) which is significantly lower than the minimum requirement. In general, the result indicated that these candidate vaccinal strains can be used for polyvalent vaccine production in the country. (C) 2013 Elsevier B.V. All rights reserved.