Mouth and genital ulcers with inflamed cartilage (MAGIC syndrome): A case report and literature review
Mouth and genital ulcers with inflamed cartilage (MAGIC syndrome): A case report and literature review
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DOI：
10.1097/00000441-199711000-00010
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发表时间：
1997-11-01
影响因子：
3.1
通讯作者：
Miura, AB
中科院分区：
文献类型：
--
作者：
Imai, H;Motegi, M;Miura, AB
一名 39 岁的女性患有复发性多软骨炎和白塞氏病，这种病被描述为口腔和生殖器溃疡伴发炎软骨综合征 (MAGIC)。血清学人类白细胞抗原分析显示 A24 (9)、A31 (19)、B56 (22)、B62 (15)、Cw6、DR4、DR9。通过聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）技术确定基因型，人类白细胞抗原等位基因分析显示DRB1 * 0406/0901、DQA1 * 0301/0301、DQB1 * 0302/0303、DPB1 * 0201/0501。甲氨蝶呤（5 毫克/周）和己酮可可碱（300 毫克/天）治疗可有效控制口腔溃疡、结节性红斑和关节炎。
A 39-year-old woman had relapsing polychondritis and Behcet's disease, which was described as mouth and genital ulcers with inflamed cartilage syndrome (MAGIC). Serologic human leukocyte antigen analysis showed A24 (9), A31 (19), B56 (22), B62 (15), Cw6, DR4, DR9. Human leukocyte antigen allele analysis revealed DRB1*0406/0901, DQA1* 0301/0301, DQB1* 0302/0303, DPB1* 0201/0501 through determining the genotype using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Treatment with methotrexate (5 mg/week) and pentoxifylline (300 mg/d) was effective to control oral ulcers, erythema nodosum, and arthritis.