Non-Hodgkin lymphoma and autoimmunity: does gender matter?
Non-Hodgkin lymphoma and autoimmunity: does gender matter?
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DOI：
10.1002/ijc.25680
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发表时间：
2011-07-15
影响因子：
6.4
通讯作者：
Roman, Eve
中科院分区：
文献类型：
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作者：
Ansell, Pat;Simpson, Jill;Roman, Eve
自身免疫性疾病在女性中更常见，而大多数非霍奇金淋巴瘤（NHL）在男性中很常见;然而，性别特异性自身免疫性淋巴瘤相关性很少报道。从791例病例（包括316例弥漫性大B细胞淋巴瘤（DLBCL）、228例滤泡性淋巴瘤（FL）、127例边缘区淋巴瘤（MZL）、64例T细胞淋巴瘤和38例套细胞淋巴瘤）和872例对照的病历中提取有关自身免疫性疾病的详细数据。自身免疫性疾病的合并患病率在女性中较高（对照组15.7%;病例组19.7%）（对照组6.6%;病例组14.5%），但男性与NHL的总体相关性更强（比值比2.4，95%置信区间：1.5-3.8）（1.3，0.9-1.9），当排除淋巴瘤诊断前一年的数据时，差异持续存在（男性2.0，1.3-3.3;女性1.2，0.8-1.8）。对于两种性别，最强的个人协会是DLBCL，MZL和T细胞淋巴瘤，与FL没有明显的关联。在女性中，MZL和干燥综合征和特发性血小板减少症之间有很强的联系，在男性中，DLBCL和类风湿性关节炎和克罗恩病之间。在两种性别中均观察到腹腔疾病和T细胞淋巴瘤之间的预期相关性。我们的研究结果增加了对这一主题的知识积累，并建议未来的研究应该分别分析男性和女性的数据。
Autoimmune disorders are more frequent in women, whereas most non-Hodgkin lymphomas (NHLs) are common in men; yet, sex-specific autoimmune-lymphoma associations are rarely reported. Detailed data on autoimmune disease were abstracted from medical records of 791 cases (including 316 diffuse large B-cell lymphomas (DLBCLs); 228 follicular lymphomas (FLs); 127 marginal zone lymphomas (MZLs); 64 T-cell lymphomas and 38 mantle cell lymphomas) and 872 controls. The combined prevalence of autoimmune disease was higher among women (15.7% controls; 19.7% cases) than men (6.6% controls; 14.5% cases), but the overall association with NHL was stronger for men (odds ratio 2.4, 95% confidence interval: 1.5-3.8) than women (1.3, 0.9-1.9), the disparity persisting when data for the year immediately preceding lymphoma diagnosis were excluded (men 2.0, 1.3-3.3; women 1.2, 0.8-1.8). For both sexes, the strongest individual associations were for DLBCL, MZL and T-cell lymphomas, with no associations evident for FL. Among women, there were strong links between MZL and both Sjogren's syndrome and idiopathic thrombocytopenia, and among men, between DLBCL and both rheumatoid arthritis and Crohn's disease. The expected association between coeliac disease and T-cell lymphoma was seen in both sexes. Our results add to the accumulating knowledge on this topic and suggest that future studies should analyze data for men and women separately.