Effect of pain and pain expectation on primary motor cortex excitability
Effect of pain and pain expectation on primary motor cortex excitability
复制标题
DOI：
10.1016/j.clinph.2011.03.026
复制
发表时间：
2011-11-01
影响因子：
4.7
通讯作者：
Mercier, Catherine
中科院分区：
文献类型：
--
作者：
Dube, Joelle A.;Mercier, Catherine
目的：研究疼痛和疼痛预期是否会影响皮质脊髓兴奋性。方法：采用经颅磁刺激方法，对15名受试者在5种实验条件下的皮质脊髓兴奋性进行测量，这些实验条件包括：(1)中性刺激；(2)实际热刺激；(3)实际疼痛；(4)预期热刺激；(5)预期疼痛。结果：两种肌肉的运动诱发电位在实验条件下均有显著差异(p<；0.005)。对比分析表明，与中性和实际热条件相比，实际疼痛导致显著的皮质脊髓抑制，而在疼痛预期条件下没有观察到任何影响。结论：我们的结果表明，急性疼痛(低到中等强度(类似于3/10))确实会引起运动抑制，但其预期不会。意义：低和短暂的疼痛可以引起运动抑制的事实表明，即使中等程度的疼痛也可能干扰既有疼痛又有运动障碍的患者的最佳运动功能。(C)2011年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: The study aimed to test whether pain and pain expectation affect corticospinal excitability.Methods: Transcranial magnetic stimulation was used to measure corticospinal excitability among 15 subjects in five experimental conditions in which thermic stimulations were applied to the hand: (1) neutral stimulus; (2) actual heat; (3) actual pain; (4) expected heat; and (5) expected pain. Motor-evoked potentials were recorded in two intrinsic hand muscles.Results: A significant difference was found between experimental conditions for both muscles (p < 0.005). Contrast analysis showed that actual pain led to a significant corticospinal inhibition compared with both neutral and actual heat conditions, whereas no effect was observed during pain expectation.Conclusions: Our results suggest that acute pain (low-to-moderate intensity (similar to 3/10)) does elicit motor inhibition but that its expectation does not.Significance: The fact that low and short-lasting pain can induce motor inhibition suggests that even moderate pain might interfere with optimal motor function in patients with both pain and motor deficits. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.