IL-6 and its receptors in coronary artery disease and acute myocardial infarction
IL-6 and its receptors in coronary artery disease and acute myocardial infarction
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DOI：
10.1016/j.cyto.2013.03.020
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发表时间：
2013-06-01
期刊：
影响因子：
3.8
通讯作者：
Thiele, Geoffrey M.
中科院分区：
文献类型：
--
作者：
Anderson, Daniel R.;Poterucha, Joseph T.;Thiele, Geoffrey M.
急性心肌梗死（AMI）患者血清中白细胞介素6（IL-6）、可溶性白细胞介素6受体（sIL-6 R）和高敏C反应蛋白（hsCRP）水平升高。本研究的目的是确定这些标志物之间的关系，以及它们与临床参数的关系，以努力辨别它们在心脏事件中的预测潜力。在心导管插入术期间，从73名AMI、稳定性冠状动脉疾病（CAD）患者和对照组中收集血清。测定生物标志物水平并与临床数据相关联。AMI组IL-6（11.75pg/ml，P < 0.05）和sIL-6 R（41，340 pg/ml，P = 0.05）均高于冠心病组和对照组。AMI组hsCRP水平（4.69 mg/L）高于对照组（2.69 mg/L，P < 0.05），而冠心病组hsCRP水平（7.4 mg/L）低于AMI组（4.69 mg/L，P < 0.05）。AMI后24 h hsCRP水平较稳定期CAD（60.46mg/L，P < 0.05）升高，且IL-6水平升高。可溶性Gp 130（sGp 130）在AMI、CAD和对照组之间无显著变化。然而，sGp 130与AM！（R = 0.587，P < 0.01），与既往AMI呈负相关（R =-0.382，P < 0.05）。AMI患者外周血单核细胞IL-6 mRNA表达水平较冠心病组和对照组显著升高（5.28倍，P < 0.01），IL-6 R和sGp 130 mRNA表达水平较冠心病组和对照组显著降低（0.374倍，P < 0.01）。这些数据支持这样的假设，即trans-IL-6受体结合可能改变细胞内信号，IL-6受体结合的阻断可能是AMI的致病因素。这些数据可以预测斑块变得不稳定和破裂的机制。(C)2013由Elsevier Ltd.出版
Biomarkers such as interleukin-6 (IL-6), soluble interleuldn-6 receptor (sIL-6R), and high sensitive C-reactive protein (hsCRP) have been reported to be elevated in acute myocardial infarction (AMI). The aim of this study is to determine the relationship between these markers during AM!, as well as their relationship to clinical parameters in an effort to discern their predictive potential in cardiac events.Serum was collected from 73 patients with; AMI, stable coronary artery disease (CAD), and controls during cardiac catheterization. Biomarker levels were determined and correlated with clinical data. IL-6 (11.75 pg/ml, P < 0.05) and sIL-6R (41,340 pg/ml, P = 0.05) were elevated in AMI compared with CAD and controls. At presentation, hsCRP was elevated in AMI patients (4.69 mg/L) compared to controls (2.69 mg/L, P < 0.05); however, there was a significant decrease in hsCRP between AMI (4.69 mg/L) and CAD patients (7.4 mg/L, P < 0.05). After 24 h post-AMI hsCRP levels were increased compared to stable CAD (60.46 mg/L, P < 0.05) and were preceded by increased IL-6 at presentation. Soluble Gp130 (sGp130) showed no significant change between AMI, CAD, and control patients. However, sGp130 positively correlated with peak troponin in AM! (R = 0.587, P < 0.01), and negatively correlated with previous AMI (R = -0.382, P < 0.05). Circulating monocyte mRNA expression isolated from selected AMI patients showed an increase in IL-6 mRNA (5.28-fold, P < 0.01) and a decrease in both IL-6R (0.374-fold, < 0.01) and sGp130 mRNA (038-fold, P < 0.01) as compared to CAD and controls.Results demonstrate that IL-6 and sIL-6R are associated with AMI and cardiac injury. These data support the hypothesis that trans-IL-6 receptor binding may alter intracellular signaling, and blocking of IL-6 receptor binding may be pathogenic in AMI. These data may be predictive of mechanism(s) by which plaques become unstable and rupture. (C) 2013 Published by Elsevier Ltd.