More is not always better: Increased fractional Anisotropy of superior longitudinal fasciculus associated with poor Visuospatial abilities in Williams syndrome
More is not always better: Increased fractional Anisotropy of superior longitudinal fasciculus associated with poor Visuospatial abilities in Williams syndrome
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DOI：
10.1523/jneurosci.3591-07.2007
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发表时间：
2007-10-31
影响因子：
5.3
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Hoeft, Fumiko;Barnea-Goraly, Naama;Reiss, Allan L.
我们使用扩散张量成像技术检测了威廉姆斯综合征(WS)患者与两个对照组(典型的发育迟缓患者和发育迟缓患者)背侧和腹侧脑干白质的完整性，并使用了三种不同的分析方法(全脑、感兴趣区和纤维束成像)。所有分析方法均一致显示，WS患者右上纵束(SLF)的分数各向异性(FA)高于两个对照组。在WS个体中，视觉空间结构缺陷和较高的FA显著相关。在WS受试者的左侧SLF或双侧下纵束中，没有观察到在不同分析方法中FA的类似增加。综上所述，这些发现提示右侧SLF异常在WS的视觉空间结构缺陷中起着特定的作用。
We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups ( typically developing and developmentally delayed) and using three separate analysis methods ( whole brain, region of interest, and fiber tractography). All analysis methods consistently showed that fractional anisotropy ( FA; a measure of microstructural integrity) was higher in the right superior longitudinal fasciculus (SLF) in WS compared with both control groups. There was a significant association with deficits in visuospatial construction and higher FA in WS individuals. Comparable increases in FA across analytic methods were not observed in the left SLF or the bilateral inferior longitudinal fasciculus in WS subjects. Together, these findings suggest a specific role of right SLF abnormality in visuospatial construction deficits in WS.