Parental smoking, socioeconomic factors, and risk of invasive meningococcal disease in children: a population based case-control study
Parental smoking, socioeconomic factors, and risk of invasive meningococcal disease in children: a population based case-control study
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DOI：
10.1136/adc.83.2.117
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发表时间：
2000-08-01
影响因子：
5.2
通讯作者：
Kriz, B
中科院分区：
文献类型：
--
作者：
Kriz, P;Bobak, M;Kriz, B
目的探讨父母吸烟、社会经济特征和室内环境对儿童侵袭性脑膜炎球菌病风险的影响。共有68例15岁以下儿童侵袭性脑膜炎球菌病的发病病例与135例来自同一学校的对照进行了比较，并在出生年份、性别和居住地方面进行了匹配。在与父母的访谈中获得了有关暴露的信息。结果侵袭性脑膜炎球菌病与父母吸烟密切相关;经社会经济因素调整后的比率为3.5（95%置信区间1.4-8.7）母亲吸烟，3.2（1.5-6.9），在家平均每天每吸20支烟，有2.7（1.3-5.4）例。患病风险与母亲受教育程度呈强负相关，与拥有汽车和周末度假屋、父亲受教育程度、拥挤程度和兄弟姐妹数量呈弱负相关，但在多变量模型中，这些相关性被降低或消除。加热和烹饪的类型（用作室内空气污染的代理）与疾病。结论侵袭性脑膜炎球菌病在儿童中的风险是强烈影响父母吸烟和不利的社会经济环境。
Aims-To investigate the effects of parental smoking, socioeconomic characteristics, and indoor environment on the risk of invasive meningococcal disease in children.Methods-Population based case-control study. A total of 68 incident cases of invasive meningococcal disease in children less than 15 years old were compared with 135 controls selected from the same school and matched for year of birth, sex, and place of residence. Information on exposures was obtained in interviews with parents.Results-Invasive meningococcal disease was strongly associated with parental smoking; rate ratios adjusted for socioeconomic factors were 3.5 (95% confidence interval 1.4-8.7) for smoking of mother, 3.2 (1.5-6.9) for smoking of father, and 2.7 (1.3-5.4) for every 20 cigarettes smoked at home on an average day. The risk of the disease was strongly inversely related to maternal education and, less strongly, to ownership of a car and of a weekend house, father's education, crowding, and the number of siblings, but these associations were reduced or eliminated in multivariate models. The type of heating and cooking (used as proxies for indoor air pollution) were not associated with the disease.Conclusion-The risk of invasive meningococcal disease in children is strongly influenced by parental smoking and unfavourable socioeconomic circumstances.