Maternal and paternal age and risk of autism spectrum disorders
Maternal and paternal age and risk of autism spectrum disorders
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DOI：
10.1001/archpedi.161.4.334
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发表时间：
2007-04-01
影响因子：
--
通讯作者：
Grether, Judith K.
中科院分区：
文献类型：
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作者：
Croen, Lisa A.;Najjar, Daniel V.;Grether, Judith K.
目的：探讨母亲和父亲的年龄和自闭症谱系障碍（ASD）的风险在children.Design之间的关联：历史出生队列研究。设置：凯泽永久（KP）在北方加州。参与者：所有独生子女出生在KP从1995年1月1日，1999年12月31日，被纳入本研究。我们确定了593名在2005年5月之前在KP门诊数据库中记录了2次或2次以上ASD诊断（国际疾病分类，第九次修订，临床修改，代码299.0或299.8）的儿童。这些孩子进行了比较，所有132 251剩余的单胎KP births.Main曝光：母亲和父亲的年龄在出生的后代。主要结果测量：相对风险（RR）估计比例风险回归模型。评估的ASD风险与母亲和父亲的年龄有关，相互调整，并调整性别，出生日期和孩子的出生顺序，母亲和父亲的教育水平，母亲和父亲的种族/ethnication.Results：ASD的风险随着母亲年龄的每10年增加而显着增加（校正的RR，1.31; 95%置信区间[CI]，1.07-1.62）和父亲年龄（RR，1.28; 95% CI，1.09-1.51）。自闭症儿童的母亲和父亲年龄的校正RR升高（母亲年龄：RR，1.18; 95% CI，0.87 - 1.60;父亲年龄：RR，1.34; 95% CI，1.06-1.69）和未另行说明的儿童发育障碍或广泛性发育障碍（母亲年龄：RR，1.45; 95% CI，1.09-1.93;父亲年龄：RR，1.24; 95% CI，0.99-1.55）。与父母年龄的协会是有点强的女孩比男孩，虽然性别差异没有统计学意义。结论：先进的母亲和父亲的年龄与ASD的风险独立相关。
Objective: To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring.Design: Historical birth cohort study.Setting: Kaiser Permanente (KP) in Northern California.Participants: All singleton children born at KP from January 1, 1995, to December 31, 1999, were included in the study. We identified 593 children who had ASD diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification, code 299.0 or 299.8) recorded 2 or more times in KP outpatient databases before May 2005. These children were compared with all 132 251 remaining singleton KP births.Main Exposures: Maternal and paternal age at birth of offspring.Main Outcome Measures: Relative risks (RRs) estimated from proportional hazards regression models. Risk of ASDs evaluated in relation to maternal and paternal age, adjusted for each other and for the sex, birth date, and birth order of the child, maternal and paternal educational level, and maternal and paternal race/ethnicity.Results: Risk of ASDs increased significantly with each 10-year increase in maternal age (adjusted RR, 1.31; 95% confidence interval [CI], 1.07-1.62) and paternal age (RR, 1.28; 95% CI, 1.09-1.51). Adjusted RRs for both maternal and paternal age were elevated for children with autistic disorder (maternal age: RR, 1.18; 95% CI, 0.871.60; paternal age: RR, 1.34; 95% CI, 1.06-1.69) and children with Asperger disorder or pervasive developmental disorder not otherwise specified (maternal age: RR, 1.45; 95% CI, 1.09-1.93; paternal age: RR, 1.24; 95% CI, 0.99-1.55). Associations with parental age were somewhat stronger for girls than for boys, although sex differences were not statistically significant.Conclusion: Advanced maternal and paternal ages are independently associated with ASD risk.