An epizootic of Nairobi sheep disease in Uganda
An epizootic of Nairobi sheep disease in Uganda
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DOI：
10.1016/s0368-1742(58)80018-1
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发表时间：
1958-01-01
期刊：
影响因子：
--
通讯作者：
WEINBREN, B. M.
中科院分区：
文献类型：
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作者：
WEINBREN, M. P.;GOURLAY, R. N.;WEINBREN, B. M.
描述了通过小鼠脑内接种分离出内罗毕羊病病毒的一次暴发。幼鼠对脑内和腹腔接种均敏感，而成年鼠仅通过前一种途径感染。胚蛋培养除一次尝试外均未成功。该病毒在绵羊中引起肾小球肾炎，在小鼠中引起脑炎，在幼鼠中引起骨骼肌炎和心肌炎。绵羊出现明显的白细胞减少和血清总蛋白下降。对节肢动物的研究表明，飞行的吸血动物不参与传播。存在蜱、鼻头蜱和无足蜱，从随后死于该病的一只羊身上取出的鼻头蜱属蜱中发现了该病毒。在其他地区的绵羊和山羊的血清和一个人的血清中发现了中和抗体。摘要作者：W. B. Bell
An outbreak, from which the virus of Nairobi sheep disease was isolated by intracerebral inoculation of mice, is described. Infant mice were susceptible to both intracerebral and intraperitoneal inoculation whereas adults were infected only by the former route. Embryonated egg culture was unsuccessful except for one attempt. The virus produced a glomerulonephritis in sheep, an encephalitis in mice, and skeletal myositis and myocarditis in infant mice. A marked leucopenia and drop in total serum protein occurred in the sheep. Studies of arthropods indicated that flying blood-suckers were not involved in transmission. Ticks, Rhipicephalus and Amblyomma, were present and the virus was recovered from ticks of the Rhipicephalus genus which were removed from a sheep that subsequently died from the disease. Neutralizing antibody was found in sera of sheep and goats in other localities and in one human serum. || ABSTRACT AUTHORS: W. B. Bell