The Many Faces of IpaB.
The Many Faces of IpaB.
复制标题
DOI：
10.3389/fcimb.2016.00012
复制
发表时间：
2016
影响因子：
5.7
通讯作者：
Picking WD
中科院分区：
文献类型：
--
作者：
Picking WL;Picking WD
III型分泌系统（T3SS）是志贺菌最重要的毒力因子。T3SS装置（T3SA）由跨越基底的基底体和顶部为称为iPad的尖端复合蛋白的外部针组成。这种纳米机器用于将效应蛋白递送到宿主细胞中以促进病原体进入。成熟的T3SS针尖复合物的关键组分是转运蛋白IpaB。IpaB在制备为重组蛋白时可以以多种状态存在，然而，它也被描述为在志贺氏菌发病机制中具有额外的作用。这个小型的审查将简要描述IpaB作为T3SS针尖蛋白，作为一个孔形成转运蛋白和作为一个效应蛋白的一些功能。还提供了IpaB的不同体外状态对其在非依赖型疫苗中的功能和重要性的潜在重要性的反思。
The type III secretion system (T3SS) is Shigella's most important virulence factor. The T3SS apparatus (T3SA) is comprised of an envelope-spanning basal body and an external needle topped by a tip complex protein called IpaD. This nanomachine is used to deliver effector proteins into host cells to promote pathogen entry. A key component of the matured T3SS needle tip complex is the translocator protein IpaB. IpaB can exist in multiple states when prepared as a recombinant protein, however, it has also been described as having additional roles in Shigella pathogenesis. This mini-review will briefly describe some of the features of IpaB as a T3SS needle tip protein, as a pore-forming translocator protein and as an effector protein. Reflection on the potential importance of the different in vitro states of IpaB on its function and importance in serotype-independent vaccines is also provided.