Nickel-catalyzed cross-coupling reaction of aryl fluorides and chlorides with Grignard reagents under nickel/magnesium bimetallic cooperation
Nickel-catalyzed cross-coupling reaction of aryl fluorides and chlorides with Grignard reagents under nickel/magnesium bimetallic cooperation
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DOI：
10.1021/ja056327n
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发表时间：
2005-12-28
影响因子：
15
通讯作者：
Nakamura, E
中科院分区：
文献类型：
--
作者：
Yoshikai, N;Mashima, H;Nakamura, E
镍催化格氏试剂与芳基(多)氟化物或(多)氯化物的交叉偶联反应可以在一个新的含羟基的三芳基膦配体的存在下有效地实现。该催化剂的高反应活性和独特的化学选择性(Arf>；ArOTf≫Arsr)归因于预先安排在配体上的镍和镁原子的协同作用，这是根据反应机理的理论模型推测的。
Nickel-catalyzed cross-coupling of Grignard reagents with aryl (poly)fluorides or (poly)chlorides can be achieved efficiently in the presence of a new triarylphosphine ligand bearing a nearby hydroxy group. The high reactivity and the unique chemoselectivity (ArF > ArOTf ≫ ArSR) of the catalysis have been attributed to synergy of nickel and magnesium atoms preorganized on the ligand, as has been surmised on the basis of theoretical modeling of the reaction mechanism.