Pleiotropic regulations of neutrophil receptors response to sepsis.
Pleiotropic regulations of neutrophil receptors response to sepsis.
复制标题
中性粒细胞受体对脓毒症反应的多效性调节。
DOI：
10.1007/s00011-016-0993-3
复制
发表时间：
2016
影响因子：
6.7
通讯作者：
孙炳伟
中科院分区：
文献类型：
--
作者：
张华峰;孙炳伟
脓毒症是一种复杂的临床疾病，在世界范围内引起高死亡率。大量关于脓毒症病理生理学的研究揭示了炎症网络的失衡，从而导致组织损伤、器官衰竭和最终死亡。中性粒细胞迁移的损害与sepsis.MethodsLiterature的结果进行了审查中性粒细胞募集和中性粒细胞受体作为多效性调节剂在脓毒症的作用。此外，我们系统地分类中性粒细胞受体在脓毒症的中性粒细胞反应，并讨论这些受体的临床意义，为治疗sepsis.ResultsIncreasing证据表明，有显着的功能障碍，在中性粒细胞招聘脓毒症，其特征在于未能迁移到感染部位。作为多效性调节因子，神经元受体在脓毒症中性粒细胞反应中起重要作用。结论神经元受体在中性粒细胞趋化迁移中起关键作用，可能成为脓毒症未来药物治疗的合适靶点。
IntroductionSepsis is a complex clinical condition that causes a high mortality rate worldwide. Numerous studies on the pathophysiology of sepsis have revealed an imbalance in the inflammatory network, thus leading to tissue damage, organ failure, and ultimately death. The impairment of neutrophil migration is associated with the outcome of sepsis.MethodsLiterature review was performed on the roles of neutrophil recruitment and neutrophil receptors as pleiotropic regulators during sepsis. Additionally, we systematically classify neutrophil receptors with regard to the neutrophil response during sepsis and discuss the clinical implications of these receptors for the treatment of sepsis.ResultsIncreasing evidence suggests that there is significant dysfunction in neutrophil recruitment during sepsis, characterized by the failure to migrate to the site of infection. Neutrophil receptors, as pleiotropic regulators, play important roles in the neutrophil response during sepsis.ConclusionsNeutrophil receptors play key roles in chemotactic neutrophil migration and may prove to be suitable targets in future pharmacological therapies for sepsis.