Transition-Metal-Catalyzed C-H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds.
Transition-Metal-Catalyzed C-H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds.
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DOI：
10.1021/acs.chemrev.6b00661
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发表时间：
2017-07-12
期刊：
影响因子：
62.1
通讯作者：
Ellman JA
中科院分区：
文献类型：
--
作者：
Hummel JR;Boerth JA;Ellman JA
过渡金属催化的 C-H 键与羰基、亚胺和相关极化 π 键的加成已成为构建极其多样化的杂原子取代产物的一种特别有效和强大的方法。通常采用容易获得且稳定的输入，并且反应通常以非常高的官能团相容性进行，并且不产生废副产物。此外，许多过渡金属催化的 C-H 键加成到极化 π 键发生在级联反应序列中，以提供快速获得各种不同杂环和碳环产物的途径。本综述重点介绍了已实现的转化的多样性、已使用的催化剂以及通过过渡金属催化 C-H 键与羰基、亚胺和相关极化 π 键加成制备的产品类型。
The transition metal-catalyzed addition of C–H bonds to carbonyls, imines and related polarized π-bonds has emerged as a particularly efficient and powerful approach for the construction of an incredibly diverse array of heteroatom substituted products. Readily available and stable inputs are typically employed, and reactions often proceed with very high functionality group compatibility and without the production of waste byproducts. Additionally, many transition metal-catalyzed C–H bond additions to polarized π-bonds occur within cascade reaction sequences to provide rapid access to a diverse array of different heterocyclic as well as carbocyclic products. This review highlights the diversity of transformations that have been achieved, catalysts that have been used, and types of products that have been prepared through the transition metal catalyzed addition of C–H bonds to carbonyls, imines and related polarized π-bonds.