Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery
Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery
复制标题
基于短肽的分子水凝胶：新型凝胶化策略及其在组织工程和药物输送中的应用
DOI：
10.1039/c2nr31149f
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发表时间：
2012-01-01
期刊：
影响因子：
6.7
通讯作者：
Yang, Zhimou
中科院分区：
文献类型：
--
作者：
Wang, Huaimin;Yang, Zhimou
分子水凝胶在组织工程和药物控释方面具有巨大的潜力。本实验室主要研究生物相容性短肽分子水凝胶及其在组织工程（特别是三维细胞培养）和药物控释中的应用。这篇专题文章首先介绍了我们最近在开发新的水凝胶形成方法方面的进展，包括二硫键还原策略和辅助特异性蛋白质-肽相互作用的策略。然后，我们介绍了我们的水凝胶在控制干细胞分化，细胞培养，聚酯材料的表面改性，通过分子自组装和抗降解的重组复杂蛋白质领域的应用。一种新型的分子水凝胶系统的疏水化合物，只形成水解过程中也包括在这篇文章中。疏水性化合物的水凝胶，特别是疏水性治疗剂的水凝胶，可以开发成用于长期递送治疗剂的无载体递送系统。通过这一领域的努力，我们相信由短肽和疏水性治疗剂形成的分子水凝胶在不久的将来可以分别实际应用于三维细胞培养和长期药物递送。
Molecular hydrogels hold big potential for tissue engineering and controlled drug delivery. Our lab focuses on short-peptide-based molecular hydrogels formed by biocompatible methods and their applications in tissue engineering (especially, 3D cell culture) and controlled drug delivery. This feature article firstly describes our recent progresses of the development of novel methods to form hydrogels, including the strategy of disulfide bond reduction and assistance with specific protein-peptide interactions. We then introduce the applications of our hydrogels in fields of controlled stem cell differentiation, cell culture, surface modifications of polyester materials by molecular self-assembly, and anti-degradation of recombinant complex proteins. A novel molecular hydrogel system of hydrophobic compounds that are only formed by hydrolysis processes was also included in this article. The hydrogels of hydrophobic compounds, especially those of hydrophobic therapeutic agents, may be developed into a carrier-free delivery system for long term delivery of therapeutic agents. With the efforts in this field, we believe that molecular hydrogels formed by short peptides and hydrophobic therapeutic agents can be practically applied for 3D cell culture and long term drug delivery in near future, respectively.