A family of hyperelastic models for human brain tissue
A family of hyperelastic models for human brain tissue
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DOI：
10.1016/j.jmps.2017.05.015
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发表时间：
2017-09-01
影响因子：
5.3
通讯作者：
Goriely, Alain
中科院分区：
文献类型：
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作者：
Mihai, L. Angela;Budday, Silvia;Goriely, Alain
在多轴载荷下对脑样品进行的实验表明，人脑组织与其他生物组织相比极为柔软，并且在剪切和压缩/拉联合作用下具有特殊的弹性响应：剪切应力随着轴压的增加而显著增加，而随着轴拉的增加而适度增加。最近的研究表明，许多广泛使用的软生物组织本构模型未能捕捉到这种特征反应。在此，以人脑组织实验为指导，我们开发了一系列建模方法，通过利用可以直接从实验数据中获得的非线性剪切模量行为的关键观察结果，捕捉在变化的简单剪切叠加在变化的轴向拉伸下的脑组织弹性。(C) 2017年作者。Elsevier Ltd.出版。
Experiments on brain samples under multiaxial loading have shown that human brain tissue is both extremely soft when compared to other biological tissues and characterized by a peculiar elastic response under combined shear and compression/tension: there is a significant increase in shear stress with increasing axial compression compared to a moderate increase with increasing axial tension. Recent studies have revealed that many widely used constitutive models for soft biological tissues fail to capture this characteristic response. Here, guided by experiments of human brain tissue, we develop a family of modeling approaches that capture the elasticity of brain tissue under varying simple shear superposed on varying axial stretch by exploiting key observations about the behavior of the nonlinear shear modulus, which can be obtained directly from the experimental data. (C) 2017 The Authors. Published by Elsevier Ltd.