The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
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DOI：
10.1016/j.scitotenv.2007.02.021
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发表时间：
2007-08-01
影响因子：
9.8
通讯作者：
Zhou, Yuanfen
中科院分区：
文献类型：
--
作者：
Chen, Bo;Hu, Yunping;Zhou, Yuanfen
尿I -羟基芘（I-OHP）是多环芳烃（PAHs）暴露的生物标志物，其水平可能受到代谢基因多态性的影响.这些知识有助于我们理解多环芳烃致癌机制的个体差异。我们调查了中国南方两个焦化厂的447名焦炉工人的基因多态性对尿1-OHP浓度的影响。调整年龄、工厂、职业暴露水平、体重指数、教育水平、饮酒、吸烟和呼吸器使用后，AhR R554 K（rs2066853），UGTIAI -3263T > G（rs 4124874）和GSTPII 105 V（rs 1695）与尿1-OHP排泄相关，p值分别为0.053、0.006和0.021。AhR R554 K、UGTIAI-3263 T> G和GSTP 111 05 V的纯合主要变异携带者和纯合次要变异携带者中尿1-OHP（几何平均值，μ mol/mol肌酸酐）的浓度如下所示：分别为4.20和5.12、5.11和3.92、4.93和2.91。在AhR R554 K GA/AA携带者（5.17对3.64 μ mol/mol肌酐，p=0.038）和UGTIAI-3263 T> G TG/GG携带者（5.67对3.38 μ mol/mol肌酐，p=0.001）的情况下，GSTT I存在携带者的尿1-OHP水平显著高于无携带者。结果表明，AhR、UGTIAI、GSTP 1和GSTT 1基因多态性与焦炉工尿1-OHP浓度相关。尿1-OHP与CYP 1A 1、CYP 1A 2、CYP 1B 1、CYP 2 E1、EPHX 1、EPHX 2基因多态性的关联性在该人群中未发现影响。(c)2007 Elsevier B. V.保留所有权利。
Urinary I -hydroxypyrene (I -OHP), a biomarker of polycyclic aromatic hydrocarbons (PAHs) exposure, may be influenced by metabolic gene polymorphisms. Such knowledge could benefit us in understanding the inter-individual difference in the mechanism of PAHs-induced carcinogenesis. We investigated the influence of gene polymorphisms on urinary 1-OHP concentrations in 447 coke oven workers from two coking plants in south China. After adjustment for age, plant, level of occupational exposure, body mass index, level of education, alcohol consumption, cigarette smoking and respirator usage, AhR R554K (rs2066853), UGTIAI -3263T > G (rs4124874) and GSTPII105V (rs1695) were associated with urinary 1-OHP excretion with the p-value of 0.053, 0.006 and 0.021, respectively. The concentrations of urinary 1-OHP (Geometric mean, mu mol/mol creatinine) in the homozygous major variant carriers and homozygous minor variant carriers for AhR R554K, UGTIAI -3263T > G and GSTP 1 11 05V were listed as follows: 4.20 and 5.12, 5.11 and 3.92, 4.93 and 2.9 1, respectively. GSTT I present carriers had a significantly higher urinary 1-OHP level than that in null carriers in the case with AhR R554K GA/AA carriers (5.17 vs. 3.64 mu mol/mol creatinine, p=0.038), as well as in the case with UGTIAI -3263T > G TG/GG carriers (5.67 vs. 3.38 mu mol/mol creatinine, p=0.001). These results showed that AhR, UGTIAI, GSTP1 andGSTTl polymorphisms were associated with urinary 1-OHP concentrations in Chinese coke oven workers. No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYPI1B1, CYP2E1, EPHX1, EPHX2 in this population. (c) 2007 Elsevier B.V. All rights reserved.