Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity
Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity
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DOI：
10.1016/j.lungcan.2008.12.020
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发表时间：
2009-07-01
期刊：
影响因子：
5.3
通讯作者：
Kohno, Shigeru
中科院分区：
文献类型：
--
作者：
Nakamura, Yoichi;Noguchi, Yuji;Kohno, Shigeru
恶性肿瘤的自然缓解是罕见的，这种缓解的生物学机制尚未解决。我们报告一例71岁的日本非小细胞肺癌患者，右肺门肿瘤和胸膜播散自发消退。NY-ESO-1是一种癌症/睾丸抗原，可以引起癌症患者的特异性免疫反应。在该患者中检测到强烈的抗ny - eso -1免疫。肿瘤细胞表达NY-ESO-1和MHC I类分子。抗ny - eso -1免疫可能促成了该患者的自发缓解。2008爱思唯尔爱尔兰有限公司版权所有。
Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient. (C) 2008 Elsevier Ireland Ltd. All rights reserved.