Differential dynamic plasticity of A1 receptive fields during multiple spectral tasks
Differential dynamic plasticity of A1 receptive fields during multiple spectral tasks
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DOI：
10.1523/jneurosci.1318-05.2005
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发表时间：
2005-08-17
影响因子：
5.3
通讯作者：
Shamma, SA
中科院分区：
文献类型：
--
作者：
Fritz, JB;Elhilali, M;Shamma, SA
听觉体验导致中枢听觉系统处理过程中的无数变化。我们最近描述了任务相关可塑性，其特征是雪貂初级听觉皮质(A1)在音调检测过程中频谱-时间感受场(STRF)的快速调制。我们推测，每个声学任务可能都有自己的“签名”STRF变化，这取决于动物执行任务所必须注意的显著线索。为了发现其他声学任务是否可以引起STRF形状的变化，我们从A1记录了雪貂，这些雪貂也接受了频率识别任务的训练。总体而言，我们发现了STRF变化的明显模式，其特征是在目标音调频率处预期的选择性增强，但在参考音调频率处也同样选择性地抑制。当顺序执行单音检测和频率辨别任务时，神经元对相同的音调做出不同的反应，反映了两种行为背景下刺激的不同预测值。所有结果都是在多单元记录和单单元记录中观察到的。我们的发现为A1中存在适应性神经元反应提供了额外的证据，这种反应可以迅速改变，以反映传入声刺激的感觉内容和不断变化的行为意义。
Auditory experience leads to myriad changes in processing in the central auditory system. We recently described task-related plasticity characterized by rapid modulation of spectro-temporal receptive fields (STRFs) in ferret primary auditory cortex (A1) during tone detection. We conjectured that each acoustic task may have its own "signature" STRF changes, dependent on the salient cues that the animal must attend to perform the task. To discover whether other acoustic tasks could elicit changes in STRF shape, we recorded from A1 in ferrets also trained on a frequency discrimination task. Overall, we found a distinct pattern of STRF change, characterized by an expected selective enhancement at target tone frequency but also by an equally selective depression at reference tone frequency. When single-tone detection and frequency discrimination tasks were performed sequentially, neurons responded differentially to identical tones, reflecting distinct predictive values of stimuli in the two behavioral contexts. All results were observed in multiunit as well as single-unit recordings. Our findings provide additional evidence for the presence of adaptive neuronal responses in A1 that can swiftly change to reflect both sensory content and the changing behavioral meaning of incoming acoustic stimuli.