Functional imaging of unilateral tinnitus using fMRI
Functional imaging of unilateral tinnitus using fMRI
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DOI：
10.1080/00016480701793743
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发表时间：
2008-01-01
影响因子：
1.4
通讯作者：
Van Dijk, P.
中科院分区：
文献类型：
--
作者：
Lanting, C. P.;De Kleine, E.;Van Dijk, P.
结论.本文表明，下丘在单侧主观性耳鸣中起着关键作用。目标.本研究的主要目的是确定耳鸣相关的神经活动在中央听觉系统的单侧耳鸣科目，并将其与对照组无耳鸣。主题和方法。对10例单侧耳鸣患者（5例男性）（5例左侧，5例右侧）和12例健康受试者（6例男性）进行功能MRI（fMRI）检查;两组均为听力正常或轻度听力损失。使用3 T Philips Intera扫描仪进行fMRI实验。听觉刺激呈现在左侧或右侧，由声压级为40或70 dB SPL的动态波纹宽带噪声组成。测量下丘和听皮层对刺激的反应。结果与无耳鸣的对照组相比，耳鸣患者的下丘对声音的反应升高。
Conclusions. This article shows that the inferior colliculus plays a key role in unilateral subjective tinnitus. Objectives. The major aim of this study was to determine tinnitus-related neural activity in the central auditory system of unilateral tinnitus subjects and compare this to control subjects without tinnitus. Subjects and methods. Functional MRI (fMRI) was performed in 10 patients (5 males) with unilateral tinnitus (5 left-sided, 5 right-sided) and 12 healthy subjects (6 males); both groups had normal hearing or mild hearing loss. fMRI experiments were performed using a 3T Philips Intera Scanner. Auditory stimuli were presented left or right and consisted of dynamically rippled broadband noise with a sound pressure level of 40 or 70 dB SPL. The responses of the inferior colliculus and the auditory cortex to the stimuli were measured. Results. The response to sound in the inferior colliculus was elevated in tinnitus patients compared with controls without tinnitus.