Pilot Study of a Nonpharmacological Intervention for Delirium Superimposed on Dementia
Pilot Study of a Nonpharmacological Intervention for Delirium Superimposed on Dementia
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DOI：
10.3928/19404921-20101001-98
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发表时间：
2011-07-01
影响因子：
1.6
通讯作者：
Litaker, Mark
中科院分区：
文献类型：
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作者：
Kolanowski, Ann M.;Fick, Donna M.;Litaker, Mark
谵妄是一种常见的神经精神综合征，最常发生在老年痴呆患者中，被称为谵妄叠加痴呆（DSD）。我们在这个试点项目的目的是证明，实施认知刺激活动是临床可行的，并有可能减少谵妄的严重程度和持续时间和功能丧失后急性护理设置。我们将新入院的DSD受试者随机分为治疗组（n = 11）和对照组（n = 5），每天对谵妄、谵妄严重程度和功能状态进行盲法评估，持续30天。与干预组相比，对照组的身体功能和精神状态随着时间的推移而明显下降。谵妄、谵妄的严重程度和注意力接近显著性，并且随着时间的推移改善有利于干预组。虽然没有统计学意义，但发现谵妄的平均（7.0 vs 3.27）和中位数（7.0 vs 3.0）天存在差异，对照组谵妄的天数更多。
Delirium is a common neuropsychiatric syndrome that occurs most frequently in older adults with dementia and is referred to as delirium superimposed on dementia (DSD). Our aim in this pilot project was to demonstrate that implementation of cognitively stimulating activities is clinically feasible and has potential to reduce delirium severity and duration and functional loss in post-acute care settings. We randomized newly admitted participants with DSD to treatment (n = 11) and control (n = 5) conditions and conducted daily blinded assessments of delirium, delirium severity, and functional status for up to 30 days. The control group had a significantly greater decrease in physical function and mental status over time compared with the intervention group. Delirium, severity of delirium, and attention approached significance, and improvement over time favored the intervention group. Although not statistically significant, a difference in mean (7.0 versus 3.27) and median (7.0 versus 3.0) days with delirium was found, with the control group having more days of delirium.