Sensitive balance of suppressing and activating effects of mesenchymal stem cells on T-cell proliferation
Sensitive balance of suppressing and activating effects of mesenchymal stem cells on T-cell proliferation
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DOI：
10.1097/01.tp.0000232450.62408.f9
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发表时间：
2006-11-27
期刊：
影响因子：
6.2
通讯作者：
Fehse, Boris
中科院分区：
文献类型：
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作者：
Fang, Lubin;Lange, Claudia;Fehse, Boris
人骨髓间充质干细胞(HMSC)具有不依赖于人白细胞抗原的免疫调节能力，有望成为临床细胞治疗的候选细胞。因此，更好地了解他们的“免疫特权”地位是当务之急。在这里，我们使用Ki-67抗原染色来评估混合淋巴细胞在hMSC作为第二方或第三方存在时的T细胞同种反应性。我们发现，间充质干细胞(MSC)的同种异体刺激活性导致T细胞增殖和IL-2分泌增加，只有在低MSC/效应比(
The human leukocyte antigen-independent immune-modulatory potential of human mesenchymal stem cells (hMSC) makes them a promising candidate for clinical cell therapy. A better understanding of their "immune-privileged" status is therefore of high priority. Here we used Ki-67-antigen staining to estimate T-cell alloreactivity in mixed lymphocyte cultures in the presence of hMSC as second or third party. We found that the allostimulatory activity of mesenchymal stem cells (MSC) leading to an increased T-cell proliferation and interleukin-2 secretion is measurable only at low MSC/effector ratios (