Role of the major histocompatibility complex class I antigens in tumor growth and metastasis.
Role of the major histocompatibility complex class I antigens in tumor growth and metastasis.
复制标题
主要组织相容性复合物 I 类抗原在肿瘤生长和转移中的作用。
作者：
K. Tanaka;T. Yoshioka;C. Bieberich;G. Jay
小鼠的主要组织相容性复合体（MHC）编码I类基因的三个亚家族，这些基因编码参与免疫调节和功能的膜结合或分泌糖蛋白（1，2）。定位于MHC的Qa和Tla亚区的I类基因编码功能未知的组织限制性分化抗原，而定位于H-2亚区的I类基因编码广泛分布的表面抗原，其功能正在分子水平上迅速确定（2，3）。最初基于它们参与移植排斥而鉴定，H-2 I类抗原与它们结构上相关的Qa和Tla I类分子的不同之处在于它们是高度多态性的。对于一些H2 I类基因，小鼠种群内的等位基因数量估计大于100（1）。越来越多的证据表明，基因组内不同I类基因之间的DNA基因间交换，通过一种称为基因转换的机制，这是产生这种多样性的原因（4）。的组合
The major histocompatibility complex (MHC) of the mouse encodes three subfamilies of class I genes that encode membrane-bound or secreted glycoproteins involved in immune regulation and functions (1, 2). While those class I genes that map to the Qa and Tla subregions of the MHC encode tissue-restricted differentiation antigens of yet unknown functions, those that map to the H-2 subregion encode widely distributed surface antigens whose functions are rapidly being defined at the molecular level (2,3). Initially identified on the basis of their participation in graft rejection, the H-2 class I antigens differ from their structurally related Qa and Tla class I molecules in that they are highly polymorphic. For some of the H2 class I genes, the number of alleles within the mouse population has been estimated to be greater than 100 (1). There is increasing evidence for intergenic exchanges of DNA between different class I genes within the genome, by a mechanism referred to as gene conversion, which is respon sible for the generation of such diversity (4). The combination of the