Osmotic stimulation in DOC-salt hypertension: vasopressin and blood pressure.
Osmotic stimulation in DOC-salt hypertension: vasopressin and blood pressure.
复制标题
DOC-盐高血压的渗透刺激：加压素和血压。
DOI：
10.1097/00004872-198606000-00008
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发表时间：
1986
影响因子：
4.9
通讯作者：
Brooks,DP
中科院分区：
文献类型：
--
作者：
Crofton,JT;Share,L;Brooks,DP
为了确定是否有一个变化的敏感性的渗透控制血管加压素释放脱氧皮质酮（DOC）盐高血压，实验进行了单侧肾切除大鼠血压正常或高血压与DOC和1%的盐水饮用。治疗3周后，向清醒的正常血压和高血压大鼠静脉输注2.5 mol/l氯化钠。在两组大鼠的输注过程中，血浆渗透压摩尔浓度和血浆加压素浓度的增加相似。高渗盐水输注增加了两组大鼠的平均动脉血压，但这种增加部分减弱了血管加压素升压拮抗剂的静脉注射。总之，血压正常和高血压大鼠对渗透压刺激的反应是相似的。两组大鼠对高渗盐水的升压反应可能部分归因于血浆加压素浓度的增加。
To determine whether there is a change in the sensitivity of the osmotic control of vasopressin release in deoxycorticosterone (DOC)-salt hypertension, experiments were performed in unilaterally nephrectomized rats that were either normotensive or were made hypertensive with DOC and given 1% saline to drink. After 3 weeks of treatment, 2.5 mol/l NaCI was infused iv into conscious normotensive and hypertensive rats. Increases in both plasma osmolality and plasma vasopressin concentration were similar throughout the course of this infusion in the two groups of rats. Hypertonic saline infusion increased the mean arterial blood pressure in the two groups of rats, but this increase was partially attenuated by the iv injection of a vasopressin pressor antagonist. In conclusion, vasopressin release in response to osmotic stimulation was similar in normotensive and hypertensive rats. The pressor response to hypertonic saline in both groups of rats could be partially attributed to the increased plasma vasopressin concentration.