Efficacy of Ceftibuten for Acute Otitis Media Caused by Hemophilus Influenzae: an Animal Study
Efficacy of Ceftibuten for Acute Otitis Media Caused by Hemophilus Influenzae: an Animal Study
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头孢布烯治疗流感嗜血杆菌引起的急性中耳炎的疗效：动物研究
DOI：
10.1177/000348949310200310
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Israel Greene
中科院分区：
文献类型：
--
作者：
Richard M. Rosenfeld;William J. Doyle;J. Seroky;J. Swarts;Israel Greene
头孢布烯是一种新型的口服头孢菌素类抗生素，对β-内酰胺酶具有独特的稳定性，而β-内酰胺酶可水解其他超广谱头孢菌素。使用灰鼠动物模型，我们比较了头孢布烯（n = 33）与生理盐水（n = 34）、氨苄西林（n = 32）和头孢克肟（n = 31）治疗由产β-内酰胺酶的不可分型流感嗜血杆菌引起的急性中耳炎的疗效。头孢布烯在中耳消毒（p <0.001）和消除积液（p <0.001）所需时间方面优于氨苄青霉素（上级）。细菌学治愈所需的平均治疗天数为头孢布烯2.57天，头孢克肟2.95天，氨苄西林7.95天，生理盐水8.16天。在治疗结束时，用头孢布烯治疗的龙猫的阳性培养物和中耳积液的患病率显著低于用氨苄青霉素治疗的动物。头孢布烯和头孢克肟之间没有观察到显著差异。这项随机、双盲实验的结果证明，头孢布烯作为氨苄西林耐药流感嗜血杆菌引起的急性中耳炎的二线药物值得进一步考虑。
Ceftibuten is a new oral cephalosporin with an unusual stability to β-lactamases that can hydrolyze other extended-spectrum cephalosporins. Using the chinchilla animal model, we compared the efficacy of ceftibuten (n = 33) with that of saline (n = 34), ampicillin (n = 32), and cefixime (n = 31) for the treatment of acute otitis media caused by β-lactamase—producing nontypeable Hemophilus influenzae. Ceftibuten was superior to ampicillin regarding the time necessary to sterilize the middle ear (p < .001) and eliminate effusion (p < .001). The mean days of therapy required for bacteriologic cure were 2.57 for ceftibuten, 2.95 for cefixime, 7.95 for ampicillin, and 8.16 for saline. At the conclusion of therapy, chinchillas treated with ceftibuten had a significantly lower prevalence of positive cultures and middle ear effusion than did animals treated with ampicillin. No significant differences were observed between ceftibuten and cefixime. The results of this randomized, investigator-blinded experiment warrant further consideration of ceftibuten as a second-line agent for acute otitis media caused by ampicillin-resistant H influenzae.
新型头孢菌素治疗急性中耳炎的疗效。
DOI：
10.1001/archotol.1987.01860040032011
发表时间：
1987
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
--
作者：
Hotaling,AJ;Doyle,WJ;Cantekin,EI
通讯作者：
Cantekin,EI