Intermittency Coding in the Primary Olfactory System: A Neural Substrate for Olfactory Scene Analysis
Intermittency Coding in the Primary Olfactory System: A Neural Substrate for Olfactory Scene Analysis
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DOI：
10.1523/jneurosci.2204-13.2014
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发表时间：
2014-01-15
影响因子：
5.3
通讯作者：
Principe, Jose C.
中科院分区：
文献类型：
--
作者：
Park, Il Memming;Bobkov, Yuriy V.;Principe, Jose C.
视觉和听觉感官输入的时空特征是动物进行场景分析不可或缺的属性。相比之下，嗅觉的研究几乎完全集中在神经系统如何分析感觉信号的质量和数量上，而在很大程度上忽略了时空维度，特别是在更长的时间尺度上。然而，对水和空气中气味羽流的湍流、间歇性结构的详细分析强烈表明，更长时间尺度的时空信息可以为动物的嗅觉场景分析提供主要线索。我们表明，龙虾初级嗅觉受体神经元（伯恩斯）的爆发子集具有编码间歇性气味信号的时间特性的意想不到的能力。每一个bORN都被调整到一个特定的刺激间隔范围，总的来说，bORN可以瞬间编码一个广泛的间歇谱。我们的理论认为存在一种新的外周机制来编码气味的时间模式，这种机制可能作为嗅觉场景分析的神经基质。
The spatial and temporal characteristics of the visual and acoustic sensory input are indispensable attributes for animals to perform scene analysis. In contrast, research in olfaction has focused almost exclusively on how the nervous system analyzes the quality and quantity of the sensory signal and largely ignored the spatiotemporal dimension especially in longer time scales. Yet, detailed analyses of the turbulent, intermittent structure of water-and air-borne odor plumes strongly suggest that spatio-temporal information in longer time scales can provide major cues for olfactory scene analysis for animals. We show that a bursting subset of primary olfactory receptor neurons (bORNs) in lobster has the unexpected capacity to encode the temporal properties of intermittent odor signals. Each bORN is tuned to a specific range of stimulus intervals, and collectively bORNs can instantaneously encode a wide spectrum of intermittencies. Our theory argues for the existence of a novel peripheral mechanism for encoding the temporal pattern of odor that potentially serves as a neural substrate for olfactory scene analysis.