A Divergent Duo: Palladium Catalyzed Carboamination in Enantioselective Desymmetrization and Regiodivergent Catalysis
A Divergent Duo: Palladium Catalyzed Carboamination in Enantioselective Desymmetrization and Regiodivergent Catalysis
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DOI：
10.1002/cctc.201901784
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发表时间：
2019-11-21
期刊：
影响因子：
4.5
通讯作者：
Gansaeuer, Andreas
中科院分区：
文献类型：
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作者：
Dolja, Etilia;Funken, Nico;Gansaeuer, Andreas
我们描述了从降冰片二烯和取代的邻碘苯胺合成伪c -2对称和伪介位双吲哚支架的区域发散性合成。Pd(0)/Josiphos系统实现了两步合成支架所需的高区域选择性催化剂控制的碳胺化反应。
We describe a regiodivergent synthesis of pseudo-C-2-symmetrical and pseudo-meso bis-indoline scaffolds from norbornadiene and substituted o-iodo-anilines. The Pd(0)/Josiphos system enables the highly regioselective catalyst controlled carboaminations required for the two step synthesis of the scaffolds.