Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance.
Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance.
复制标题
内皮细胞分泌的纤溶酶原激活剂抑制剂-1 增加体外纤维蛋白凝块的纤溶抵抗：内皮细胞在溶栓抵抗中发挥关键作用的证据。
作者：
S. Handt;W. Jerome;L. Tietze;R. Hantgan
Time-dependent thrombolytic resistance is a critical problem in thrombolytic therapy for acute myocardial infarction. Platelets have been regarded as the main source of plasminogen activator inhibitor-1 (PAI-1) found in occlusive platelet-rich clots. However, endothelial cells are also known to influence the fibrinolytic capacity of blood vessels, but their ability to actively mediate time-dependent thrombolytic resistance has not been fully established. We will show that, in vitro, tumor necrosis factor-alpha-stimulated endothelial cells secrete large amounts of PAI-1 over a period of hours, which then binds to fibrin and protects the clot from tissue plasminogen activator-induced fibrinolysis. In vivo, endothelial cells covering atherosclerotic plaques are influenced by cytokines synthesized by plaque cells. Therefore, we propose that continuous activation of endothelial cells in atherosclerotic blood vessels, followed by elevated PAI-1 secretion and storage of active PAI-1 in the fibrin matrix, leads to clot stabilization. This scenario makes endothelial cells a major factor in time-dependent thrombolytic resistance.
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影响因子：
3.4
作者：
DIAMOND, SL;ANAND, S
通讯作者：
ANAND, S
影响因子：
20.3
作者：
J. Braaten;S. Handt;WG Jerome;John P. Kirkpatrick;Jon C. Lewis;R. Hantgan
通讯作者：
J. Braaten;S. Handt;WG Jerome;John P. Kirkpatrick;Jon C. Lewis;R. Hantgan
内皮细胞纤溶组装。
影响因子：
5.2
作者：
Nachman,RL;Hajjar,KA
通讯作者：
Hajjar,KA
急性心肌梗死静脉溶栓后冠状动脉通畅和左心室功能的汇总分析。
DOI：
10.1016/0002-9149(94)90552-5
发表时间：
1994
期刊：
The American journal of cardiology
影响因子：
--
作者：
Granger,CB;White,HD;Bates,ER;Ohman,EM;Califf,RM
通讯作者：
Califf,RM
影响因子：
20.3
作者：
S. Kunitada;G. FitzGerald;D. Fitzgerald
通讯作者：
S. Kunitada;G. FitzGerald;D. Fitzgerald