Simplified quantification of FDG metabolism in tumors using the autoradiographic method is less dependent on the acquisition time than SUV
Simplified quantification of FDG metabolism in tumors using the autoradiographic method is less dependent on the acquisition time than SUV
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DOI：
10.1016/j.nucmedbio.2011.02.003
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发表时间：
2011-08-01
影响因子：
3.1
通讯作者：
Buck, Alfred
中科院分区：
文献类型：
--
作者：
Burger, Irene A.;Burger, Cyrill;Buck, Alfred
标准摄取值 (SUV) 是 (18)F-氟脱氧葡萄糖 (FDG) 摄取最常用的半定量测量方法。我们测试了这样的假设：采用基于人群的输入曲线的放射自显影方法产生了由通量值 Ki 表示的 FDG 代谢的近似值，与 SUV 相比，该近似值对采集时间点的依赖性较小。方法：我们分析了 20 名胸部肿瘤患者（16 名男性，年龄 65 +/- 10 岁）。使用 INTEGO PET 输注系统注射 350 MBq FDG 后，采集持续时间为 10 至 300 秒的 35 次扫描，直至 45 分钟。使用 Patlak 方法 (Ki(pathak)) 计算 FDG 通量，并使用仅使用最后一次采集的放射自显影方法和单个图像衍生输入函数 (Ki(autoreal)) 以及基于群体的输入函数 (Ki(autonorm)) 进行量化。在模拟研究中，计算了30至90分钟的肿瘤SUV、肿瘤与血液比和肿瘤Ki值的时程。结果：放射自显影方法和Patlak方法获得的不同肿瘤的FDG通量值（Ki）表现出高度相关性。模拟研究显示，从 50 分钟到 70 分钟，SUV 值增加了 16.8 +/- 3.3%，但放射自显影方法计算的 Ki 值仅变化 1.3 +/- 2.8%。 结论：与 SUV 相比，放射自显影 Ki 值由于多种原因而具有优势。首先，与 SUV 相比，它们对购买时间的依赖要小得多。其次，他们的计算不需要了解体重或注射的活动。此外，这些值与通过广泛接受的 Patlak 方法获得的值相当。该方法可以在临床环境中轻松实施，因为它仅使用一次静态扫描。 (C) 2011 Elsevier Inc. 保留所有权利。
The standard uptake value (SUV) is the most often used semi-quantitative measure of (18)F-fluorodeoxyglucose (FDG) uptake. We tested the hypothesis that the autoradiographic method with a population-based input curve yields an approximation of FDG metabolism represented by the flux value Ki, which is less dependent on the acquisition time point than SUV.Methods: We analyzed 20 patients with chest tumors (16 males, age 65 +/- 10 years). After injection of 350 MBq FDG using the INTEGO PET infusion system, a series of 35 scans of 10- to 300-s duration were acquired until 45 min. FDG flux was calculated using the Patlak method (Ki(pathak)) and also quantified with the autoradiographic method using the last acquisition only and the individual image-derived input function (Ki(autoreal)), as well as with a population-based input function (Ki(autonorm)). In a simulation study, the time courses of tumor SUV, tumor-to-blood ratio and tumor Ki values were calculated from 30 to 90 min.Results: The FDG flux values (Ki) of the different tumors, obtained with the autoradiographic methods and the Patlak method, showed a high correlation. The simulation study showed a 16.8 +/- 3.3% increase in the SUV values from 50 to 70 min, but only a 1.3 +/- 2.8% change in the Ki values calculated with the autoradiographic method.Conclusion: Compared to the SUV, the autoradiographic Ki values are advantageous for various reasons. First, they are much less dependent on the time of acquisition than the SUV. Second, their calculation does not require the knowledge of the body weight or the injected activity. Furthermore, the values are comparable to the ones obtained with the widely accepted Patlak method. The method can be easily implemented in a clinical setting, as it uses only one static scan. (C) 2011 Elsevier Inc. All rights reserved.