The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis.
The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis.
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DOI：
10.1186/s13643-017-0442-6
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发表时间：
2017-03-09
影响因子：
3.7
通讯作者：
Owens JA
中科院分区：
文献类型：
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作者：
Dodd JM;Grivell RM;Louise J;Deussen AR;Giles L;Mol BW;Vinter C;Tanvig M;Jensen DM;Bogaerts A;Devlieger R;Luoto R;McAuliffe F;Renault K;Carlsen E;Geiker N;Poston L;Briley A;Thangaratinam S;Rogozinska E;Owens JA
这项个体参与者数据荟萃分析（IPDMA）的目的是评估超重或肥胖孕妇的饮食和生活方式干预对3-5岁后期孕产妇和幼儿结局的影响。我们将建立在已建立的国际妊娠期体重管理（i-weight Management in pregnancy）IPD协作网络的基础上，确定了对超重或肥胖的孕妇进行随机饮食和生活方式干预的研究人员，以及已经或正在进行参与者的持续儿童随访。主要的母体结局是母体代谢综合征的诊断。主要的儿童结局是BMI超过90%。我们确定了7项相关试验，涉及5425名妊娠期超重或肥胖的妇女，约3544名妇女和儿童的随访评估可纳入荟萃分析。拟议的IPDMA提供了一个机会，以评估超重或肥胖孕妇的饮食和生活方式干预对后期孕产妇和幼儿健康结果的影响，包括肥胖风险。这些知识对于有效地将研究成果转化为临床实践和公共卫生政策至关重要。该IPD已前瞻性注册（PROSPERO），ID编号CRD 42016047165。本文的在线版本（doi：10.1186/s13643-017-0442-6）包含补充材料，可供授权用户使用。
The aim of this individual participant data meta-analysis (IPDMA) is to evaluate the effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early childhood outcomes at ages 3–5 years. We will build on the established International Weight Management in Pregnancy (i-WIP) IPD Collaborative Network, having identified researchers who have conducted randomised dietary and lifestyle interventions among pregnant women who are overweight or obese, and where ongoing childhood follow-up of participants has been or is being undertaken. The primary maternal outcome is a diagnosis of maternal metabolic syndrome. The primary childhood outcome is BMI above 90%. We have identified 7 relevant trials, involving 5425 women who were overweight or obese during pregnancy, with approximately 3544 women and children with follow-up assessments available for inclusion in the meta-analysis. The proposed IPDMA provides an opportunity to evaluate the effect of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early childhood health outcomes, including risk of obesity. This knowledge is essential to effectively translate research findings into clinical practice and public health policy. This IPD has been prospectively registered (PROSPERO), ID number CRD42016047165. The online version of this article (doi:10.1186/s13643-017-0442-6) contains supplementary material, which is available to authorized users.