Posttraumatic epilepsy may be a state in which underlying epileptogenicity involves focal cortical dysplasia
Posttraumatic epilepsy may be a state in which underlying epileptogenicity involves focal cortical dysplasia
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DOI：
10.1016/j.yebeh.2020.107352
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发表时间：
2021-01-15
影响因子：
2.6
通讯作者：
Okanishi, Tohru
中科院分区：
文献类型：
--
作者：
Sakakura, Kazuki;Fujimoto, Ayataka;Okanishi, Tohru
创伤后癫痫的发生率从1%到30%不等。关于创伤性脑损伤（TBI）相关癫痫（TRE）的潜在癫痫发生知之甚少，因为没有在神经病理学方面对TRE和无癫痫的TBI进行比较。因此，我们推测，不同的神经病理因素之间可能存在TRE和TBI无癫痫。本研究的目的是澄清TRE和TBI没有epilepsy.Methods之间的差异：我们研究的患者经历了严重的头部创伤，并接受了脑外科手术。患者年龄范围为9-71岁。癫痫组包括难治性癫痫患者，非癫痫组包括非癫痫患者。病理结果，年龄，性别和头部外伤的原因进行统计学比较这两组之间。结果：本研究涉及10例患者，其中9人符合纳入标准。癫痫组所有患者的病理结果包括局灶性皮质发育不良（FCD）（p = 0.012）。结论：TRE与TBI无癫痫的差异是TRE患者FCD的基础。(C)2020爱思唯尔公司All rights reserved.
Introduction: The occurrence rate of posttrauma epilepsy ranges widely from 1% to 30%. Little is known about the underlying epileptogenesis of traumatic brain injury (TBI)-related epilepsy (TRE), because no comparison between TRE and TBI without epilepsy has been performed in terms of neuropathology. Therefore, we postulated that different neuropathological factors may be present between TRE and TBI without epilepsy. The purpose of this study was to clarify differences between TRE and TBI without epilepsy.Methods: We studied patients who experienced severe head trauma and underwent brain surgery. The age range of the patients was 9-71 years old. Patients with medically resistant epilepsy were included in the Epilepsy group, and patients without epilepsy were included in the nonepilepsy group. Pathological findings, age, sex, and cause of head trauma were statistically compared between these two groups.Results: This study involved 10 patients, nine of whom met the inclusion criteria. Pathological findings for all patients in the Epilepsy group included focal cortical dysplasia (FCD) (p = 0.012).Conclusion: The difference between TRE and TBI without epilepsy was underlying FCD in patients with TRE. (C) 2020 Elsevier Inc. All rights reserved.