Thyroid hormone-dependent metamorphosis in a direct developing frog
Thyroid hormone-dependent metamorphosis in a direct developing frog
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DOI：
10.1073/pnas.050501097
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发表时间：
2000-03-14
影响因子：
11.1
通讯作者：
Elinson, RP
中科院分区：
文献类型：
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作者：
Callery, EM;Elinson, RP
直接发育的无尾两栖动物，Eleutherodactylus coqui，没有蝌蚪，孵化成一只小青蛙。我们研究了变质触发因素甲状腺激素(TH)在这种不寻常的个体发育中的作用，甲状腺激素受体TRα和TRβ的表达模式与间接显影剂的表达模式相似。在甲状腺成熟前后，当发生使人联想到变态的重塑事件时，trβmRNA水平显著增加。甲状旁腺激素他巴唑治疗抑制了这种重塑，与TH联合治疗后又重新启动。尽管直接显影剂的个体发育发生了根本的变化，但它们仍然经历着TH依赖的变态，这种变态发生在孵化之前。我们提出了一种新的无尾两栖动物直接发育进化模型。
The direct developing anuran, Eleutherodactylus coqui, lacks a tadpole, hatching as a tiny frog. We investigated the role of the metamorphic trigger, thyroid hormone (TH), in this unusual ontogeny, Expression patterns of the thyroid hormone receptors, TR alpha and TR beta, were similar to those of indirect developers. TR beta mRNA levels increased dramatically around the time of thyroid maturation, when remodeling events reminiscent of metamorphosis occur. Treatment with the goitrogen methimazole inhibited this remodeling, which was reinitiated on cotreatment with TH. Despite their radically altered ontogeny, direct developers still undergo a TH-dependent metamorphosis, which occurs before hatching. We propose a new model for the evolution of anuran direct development.