Breakthrough fungemia due to Candida fermentati with fks1p mutation under micafungin treatment in a cord blood transplant recipient.
Breakthrough fungemia due to Candida fermentati with fks1p mutation under micafungin treatment in a cord blood transplant recipient.
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脐带血移植受者在米卡芬净治疗下因具有 fks1p 突变的发酵念珠菌而出现突破性真菌血症。
DOI：
10.1111/tid.12634
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发表时间：
2017
影响因子：
2.6
通讯作者：
Tojo A.
中科院分区：
文献类型：
--
作者：
Konuma T;Takahashi S;Kiyuna T;Miharu Y;Suzuki M;Shibata H;Kato S;Takahashi S;Tojo A.
在异基因造血细胞移植受者中预防性使用抗真菌药物显示非白念珠菌血症的发生率增加。我们在此报告一例成人T细胞白血病患者在脐带血移植后接受米卡芬净治疗期间因发酵念珠菌引起念珠菌血症。在第47天通过核糖体RNA基因的内部转录间隔区测序鉴定分离株。对分离株fks1p热点区域的测序显示天然存在的氨基酸取代，这降低了棘白菌素的敏感性。该病例强调了在接受米卡芬净治疗的患者中发生发酵念珠菌引起的突破性念珠菌血症。
The prophylactic use of antifungal drugs in allogeneic hematopoietic cell transplant recipients has revealed that the rate of non‐albicanscandidemia has increased. We herein report the case of a patient with adult T‐cell leukemia who developed candidemia due toCandida fermentatiduring micafungin treatment after cord blood transplantation. The isolate was identified on day 47 by sequencing of the internal transcribed spacer region of the ribosomal RNA gene. The sequencing of the hot spot region of fks1p of isolate revealed naturally occurring amino acid substitutions, which conferred reduced echinocandin susceptibility. This case highlights that breakthrough candidemia due toC. fermentatioccurred in a patient receiving micafungin treatment.