RAMP LIKE PROTEINS RTP and REEP Family of Proteins
RAMP LIKE PROTEINS RTP and REEP Family of Proteins
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DOI：
10.1007/978-1-4614-2364-5_7
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Matsunami, Hiroaki
中科院分区：
文献类型：
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作者：
Mainland, Joel;Matsunami, Hiroaki
当在异源细胞中表达时，哺乳动物气味受体（OR）通常保留在内质网（ER）中。RTP（受体转运蛋白）和REEP（受体表达增强蛋白）蛋白家族首先被鉴定为OR的伴侣，促进细胞表面表达并导致异源细胞系统中的功能反应。与RAMP一样，RTP和REEP蛋白似乎与GPCR合作促进细胞表面表达。与RAMP不同，它们似乎不会改变伴侣受体的药理学。
Mammalian odorant receptors (ORs) are typically retained in the endoplasmic reticulum (ER) when expressed in heterologous cells. The RTP (Receptor-Transporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.