Closed-loop control of blood glucose levels in critically ill patients
Closed-loop control of blood glucose levels in critically ill patients
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DOI：
10.1177/0310057x0203000306
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发表时间：
2002-06-01
影响因子：
1.5
通讯作者：
van Heerden, PV
中科院分区：
文献类型：
--
作者：
Chee, F;Fernando, T;van Heerden, PV
构建了一个闭环控制系统，用于危重患者自动静脉输注胰岛素以控制血糖水平（BSL）。我们描述了该系统的发展。共招募了9名受试者对对照系统进行临床测试。在接受BSL闭环控制的患者中，控制器在没有任何手动干预的情况下仅控制了一名患者的高血压。闭环控制的平均BSL接近目标值6-10 mmol/l，且与人工维持BSL相比偏差较小，说明采用滑模算法的闭环BSL控制是可行的。当前系统中的主要缺陷是皮下葡萄糖传感器在该设置中使用时的不可靠性。这一缺陷要求在系统开发过程中，在使用过程中保持高度警惕。
A closed-loop control system was constructed for automatic intravenous infusion of insulin to control blood sugar levels (BSL) in critically ill patients. We describe the development of the system. A total of nine subjects were recruited to clinically test the control system. In the patients who underwent closed-loop control of BSL, the controller managed to control only one patient's glycaemia without any manual intervention. The average BSL attained during closed-loop control approached the target range of 6-10 mmol/l, and had less deviation than when BSL had been maintained manually.We conclude that closed-loop BSL control using a sliding scale algorithm is feasible. The main deficiency in the current system is unreliability of the subcutaneous glucose sensor when used in this setting. This deficiency mandates high vigilance during use of the system as it is being developed.