Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation
Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation
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DOI：
10.1016/j.bbmt.2009.04.008
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发表时间：
2009-08-01
影响因子：
4.3
通讯作者：
Uchiyama, Takashi
中科院分区：
文献类型：
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作者：
Kanda, Junya;Mizumoto, Chisaki;Uchiyama, Takashi
铁超载与异基因造血干细胞移植（HSCT）并发症的关联已在以往的研究中提出。由于hepcidin在调节铁稳态中起着核心作用，我们分析了移植前血清hepcidin-25水平与异基因HSCT后早期感染并发症之间的关系。我们研究了55例连续的成人患者，中位年龄为47岁（范围：20-64岁），他们在我们的机构接受了异基因HSCT治疗恶性血液病。32例患者有骨髓性恶性肿瘤，其余23例有淋巴恶性肿瘤。研究中患者的移植前血清铁调素水平中位数为21.6 ng/mL（范围：1.4-371 ng/mL），与健康志愿者相当（中位数：19.1 ng/mL [范围：2.3-37 ng/mL]; n = 17）。当根据移植前hepcidin-25水平比较第100天记录的细菌和巨细胞病毒（CMV）感染的累积发生率时，高hepcidin组（= 50 ng/mL; n = 17）的细菌感染发生率（而不是CMV感染）显著高于低hepcidin组（= 10 ng/mL; n = 17）。
The association of iron overload with complications of allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested in previous studies. Because hepcidin plays a central role in the regulation of iron homeostasis, we analyzed the association between pretransplant serum hepcidin-25 levels and early infectious complications after allogeneic HSCT We studied 55 consecutive adult patients with a median age of 47 years (range: 20-64 years) who underwent allogeneic HSCT for hematologic malignancies at our institution. Thirty-two patients had myelogenous malignancies; the remaining 23 had lymphogenous malignancies. The median pretransplant serum hepcidin level of patients in the study was 21.6 ng/mL (range: 1.4-371 ng/mL), which was comparable to that of healthy volunteers (median: 19.1 ng/mL [range: 2.3-37 ng/mL]; n = 17). When cumulative incidences of documented bacterial and cytomegalovirus (CMV) infections at day 100 were compared according to pretransplant hepcidin-25 levels, the incidence of bacterial, but not CMV, infection, was significantly higher in the high-hepcidin group (= 50 ng/mL; n = 17) than in the low-hepcidin group (