Generalized half-center oscillators with short-term synaptic plasticity
Generalized half-center oscillators with short-term synaptic plasticity
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DOI：
10.1103/physreve.102.032406
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发表时间：
2020-09-10
影响因子：
2.4
通讯作者：
Shilnikov, A.
中科院分区：
文献类型：
--
作者：
Baruzzi, V.;Lodi, M.;Shilnikov, A.
我们如何开发简单而又现实的模型，来描述被称为中央模式发生器（CPG）的小神经回路，它有助于在活体动物中产生复杂的多相运动？在本文中，我们介绍了一个新的模型（设计标准）的广义半中心振荡器，（池）神经元耦合的快/慢抑制性和兴奋性突触，产生交替爆发或其他节奏模式，其特征在于不同的相位滞后，这取决于感官或其他外部输入。我们还展示了如何校准其参数，生理和功能的标准和分叉分析的基础上。该模型以生物药理学合理的方式解释了短期神经调节，并且是开发更现实和功能准确的CPG模型的构建块。通过实例和反例说明了该设计方法的通用性和有效性。
How can we develop simple yet realistic models of the small neural circuits known as central pattern generators (CPGs), which contribute to generate complex multiphase locomotion in living animals? In this paper we introduce a new model (with design criteria) of a generalized half-center oscillator, (pools of) neurons reciprocally coupled by fast/slow inhibitory and excitatory synapses, to produce either alternating bursting or other rhythmic patterns, characterized by different phase lags, depending on the sensory or other external input. We also show how to calibrate its parameters, based on both physiological and functional criteria and on bifurcation analysis. This model accounts for short-term neuromodulation in a biophysically plausible way and is a building block to develop more realistic and functionally accurate CPG models. Examples and counterexamples are used to point out the generality and effectiveness of our design approach.