Magnesium and Parathyroid Hormone Changes to Magnesium-Free Dialysate in Continuous Ambulatory Peritoneal Dialysis Patients
Magnesium and Parathyroid Hormone Changes to Magnesium-Free Dialysate in Continuous Ambulatory Peritoneal Dialysis Patients
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连续非卧床腹膜透析患者无镁透析液中镁和甲状旁腺激素的变化
DOI：
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发表时间：
1994
影响因子：
2.8
通讯作者：
M. Yanai
中科院分区：
文献类型：
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作者：
Susumu Takahashi;K. Okada;M. Yanai
目的 为了使血清镁（Mg）浓度正常化，连续不卧床腹膜透析（CAPD）患者透析液镁浓度趋于降低。本研究的目的是评估镁对甲状旁腺激素（PTH）的影响。设计使用无镁透析液 8 周的前瞻性研究。设置透析服务，日本大学医学院板桥医院。患者 5 名稳定的 CAPD 患者（1 名男性；4 名女性；年龄 49.7±1.3 岁；CAPD 持续时间 27±9 个月）。主要指标每隔4周测定一次血清镁、血清高敏PTH和单个核细胞镁含量。结果 与基线相比，第 4 周（p<0.01）和第 8 周（p<0.01）血清 Mg 浓度显着降低，第 4 周（p<0.05）和第 8 周（p<0.05）血清 PTH 显着升高。然而，第8周的PTH水平低于第4周。此外，单个核细胞中的Mg含量在第4周（p<0.01）和第8周（p<0.01）显着降低。血清离子钙和磷酸盐浓度没有变化。结论 无镁透析液去除镁导致 CAPD 患者镁耗竭。此外，镁缺乏会在4周时刺激PTH合成或分泌，但在8周时PTH合成或分泌还受到其他因素的影响。
Objective For the normalization of serum magnesium (Mg) concentration, dialysate Mg concentration tends to be reduced in continuous ambulatory peritoneal dialysis (CAPD) patients. The aim of this study was to evaluate the influence of Mg on parathyroid hormone (PTH). Design Prospective study of the utilization of Mg-free dialysate for 8 weeks. Setting Dialysis service, Itabashi Hospital, Nihon University School of Medicine. Patients Five stable CAPD patients (1 male; 4 female; age 49.7±1.3 years; duration of CAPD 27±9 months). Main Outcome Measures Serum Mg, serum high sensitive PTH, and Mg content in mononuclear cells were measured at 4-week intervals. Results In comparison to baseline, serum Mg concentration was significantly reduced at week 4 (p<0.01) and week 8 (p<0.01), and serum PTH was significantly increased at week 4 (p<0.05) and at week 8 (p<0.05). However, the PTH level at week 8 was lower than that at week 4. Furthermore, the Mg content in mononuclear cells was significantly decreased at week 4 (p<0.01) and at week 8 (p<0.01). Serum -ionized calcium and phosphate concentrations did not change. Conclusions The removal of Mg by Mg-free dialysate leads to Mg depletion in CAPD patients. In addition, Mg depletion stimulates PTH synthesis or secretion at 4 weeks, but at 8 weeks PTH synthesis or secretion is also influenced by other factors.
低钙血症对于慢性肾功能衰竭继发性甲状旁腺功能亢进症的发生可能不是必需的。
DOI：
10.1172/jci112666
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Lopez-Hilker,S;Galceran,T;Chan,YL;Rapp,N;Martin,KJ;Slatopolsky,E
通讯作者：
Slatopolsky,E