The genetics of aging.

The genetics of aging.
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DOI:
10.1080/21548331.1997.11443423
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发表时间:
1997-02
期刊:
Hospital practice
影响因子:
--
通讯作者:
George M. Martin
George M. Martin
中科院分区:
其他
文献类型:
--
作者:
George M. Martin

文献摘要

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不存在衰老程序,也不存在衰老基因。相反,我们变老是因为进化没有理由保护我们免受晚年多个基因不受欢迎的行为的影响。尽管如此,每一项有害突变或多态性的发现至少都会增加其他有益等位基因的理论可能性,并为理解衰老背后的生物分子机制提供线索。
There is no aging program, nor is there an aging gene. Instead, we age because evolution has no reason to protect us against unwelcome actions of multiple genes late in life. Still, every discovery of a harmful mutation or polymorphism raises at least the theoretical possibility of other, beneficial alleles- and offers clues for understanding the biomolecular mechanisms that underlie senescence.