Superfast and Water-Insensitive Polymerization on alpha-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the Initiator
Superfast and Water-Insensitive Polymerization on alpha-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the Initiator
复制标题
四烷基羧酸铵作为引发剂超快速且水不敏感的α-氨基酸N-羧酸酐聚合制备多肽
DOI：
10.1002/anie.202103540
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liu Runhui
中科院分区：
文献类型：
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作者：
Wu Yueming;Chen Kang;Wu Xue;Liu Longqiang;Zhang Weiwei;Ding Yun;Liu Shiqi;Zhou Min;Shao Ning;Ji Zhemin;Chen Jiacheng;Zhu Minghui;Liu Runhui
为了高效合成多肽，我们设计了四烷基羧酸铵引发的α -氨基酸n -羧酸氢化物（NCA）超快速聚合。羧酸盐作为一类新型的NCA聚合引发剂，无需额外的催化剂即可引发超快速的NCA聚合，且无需使用手套箱即可在环境条件下的开放式容器中进行聚合。四烷基羧酸铵在NCA上引发的聚合很容易得到至少有15个嵌段的共聚物。此外，该方法避免了繁琐的纯化步骤，可以在水环境中直接聚合粗NCAs以制备多肽和一锅合成多肽纳米颗粒。这些优点以及四烷基羧酸铵引发的NCA聚合反应条件温和，表明其在多肽的功能探索和应用方面具有巨大的潜力。
We design the tetraalkylammonium carboxylate‐initiated superfast polymerization on α‐amino acidN‐carboxyanhydrides (NCA) for efficient synthesis of polypeptides. Carboxylates, as a new class of initiator for NCA polymerization, can initiate the superfast NCA polymerization without the need of extra catalysts and the polymerization can be operated in open vessels at ambient condition without the use of glove box. Tetraalkylammonium carboxylate‐initiated polymerization on NCA easily affords block copolymers with at least 15 blocks. Moreover, this method avoids tedious purification steps and enables direct polymerization on crude NCAs in aqueous environments to prepare polypeptides and one‐pot synthesis of polypeptide nanoparticles. These advantages and the mild polymerization condition of tetraalkylammonium carboxylate‐initiated NCA polymerization imply its great potential in functional exploration and application of polypeptides.