Impact of a novel family-centered values clarification tool on adolescent sperm banking attempts at the time of a new cancer diagnosis
Impact of a novel family-centered values clarification tool on adolescent sperm banking attempts at the time of a new cancer diagnosis
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DOI：
10.1007/s10815-021-02092-6
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发表时间：
2021-02-10
影响因子：
3.1
通讯作者：
Gerhardt, Cynthia A.
中科院分区：
文献类型：
--
作者：
Nahata, Leena;Dattilo, Taylor M.;Gerhardt, Cynthia A.
超过一半的男性在儿童癌症治疗后经历生育障碍，这通常会导致心理社会困扰。然而，生育力保持（FP）仍然没有得到充分利用。本研究的目的是确定实施以家庭为中心的FP值澄清工具对新诊断患有癌症的青少年男性精子库尝试的可行性和影响，并确定精子库尝试的关键决定因素。方法采用前瞻性研究方法，对12-25岁男性癌症患者家庭进行癌症治疗前的随访。41个家庭中有39个同意参与（95%）; 98名参与者（32名青少年，37名母亲，29名父亲）完成了以家庭为中心的青少年精子库价值澄清工具（FAST）。分析评估了FAST对银行尝试的影响，并检查了人口统计学/医学特征，FAST分量表（感知威胁，好处，障碍）和银行尝试之间的关联。结果：23名（59%）青少年尝试存钱，相比之下，8名青少年（33%）在基线评估（p= 0.04）。银行尝试与青少年报告的感知威胁（r（pb）= 0.45，p= 0.01）和收益（r（pb）= 0.57，p= 0.01）之间存在显著关联。只有母亲对青少年感知的威胁（r（pb）=.42，p=.01）和利益（r（pb）=.47，p=.003）的代理报告与银行尝试相关，而父亲自我报告的感知利益（r（pb）=.43，p=.03），自我报告的障碍（r（pb）=.49，p=.01）和青少年感知的威胁（r（pb）=.38，p= 0.04）和收益（r（pb）= 0.59，p= 0.02）与银行尝试相关。结论：在癌症治疗前实施以家庭为中心的FP值澄清工具后，青少年精子库尝试率显着增加。调查结果强调，在计划生育工作中，针对青少年及其父母，特别是父亲的重要性。
Purpose Over half of males experience fertility impairment after childhood cancer therapy, which often causes psychosocial distress. Yet, fertility preservation (FP) remains underutilized. The goals of this study were to determine the feasibility and impact of implementing a family-centered FP values clarification tool on sperm banking attempts among adolescent males newly diagnosed with cancer, and identify key determinants of banking attempts. Methods A prospective pilot study was conducted among families of males (12-25 years old), prior to cancer therapy. Thirty-nine of 41 families agreed to participate (95%); 98 participants (32 adolescents, 37 mothers, 29 fathers) completed the Family-centered Adolescent Sperm banking values clarification Tool (FAST). Analyses assessed the impact of the FAST on banking attempts and examined associations between demographic/medical characteristics, FAST subscales (perceived threat, benefits, barriers), and banking attempts. Results Twenty-three (59%) adolescents attempted to bank, compared to 8 adolescents (33%) during baseline assessment (p=.04). Significant associations were identified between banking attempts and adolescents' report of perceived threat (r(pb)=.45, p=.01) and benefits (r(pb)=.57, p=.01). Only mothers' proxy reports of adolescent perceived threat (r(pb)=.42, p=.01) and benefits (r(pb)=.47, p=.003) were associated with banking attempts, while fathers' self-reported perceived benefits (r(pb)=.43, p=.03), self-reported barriers (r(pb)=.49, p=.01), and proxy reports of adolescent perceived threat (r(pb)=.38, p=.04) and benefits (r(pb)=.59, p=.02) were associated with banking attempts. Conclusion Adolescent sperm banking attempt rates significantly increased after implementation of a family-centered FP values clarification tool prior to cancer treatment. Findings underscore the importance of targeting both adolescents and their parents, particularly fathers, in FP efforts.