VITAMIN-D IS NECESSARY FOR REPRODUCTIVE FUNCTIONS OF THE MALE-RAT
VITAMIN-D IS NECESSARY FOR REPRODUCTIVE FUNCTIONS OF THE MALE-RAT
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DOI：
10.1093/jn/119.5.741
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发表时间：
1989-05-01
影响因子：
4.2
通讯作者：
DELUCA, HF
中科院分区：
文献类型：
--
作者：
KWIECINSKI, GG;PETRIE, GI;DELUCA, HF
研究维生素D缺乏对雄性大鼠生育力和生殖能力的影响。雄性断奶大鼠被喂食维生素D缺乏或维生素D充足的食物，直到成熟，并与年龄匹配、维生素D充足的雌性交配。缺乏维生素D的男性具有生殖能力。然而，与维生素D充足的男性相比，维生素D缺乏的男性的成功交配，即女性阴道中精子的存在，减少了45%。与维生素D充足的雄性受精雌性相比，缺乏维生素D的雄性受精的受精率(精子阳性雌性受孕成功)下降了73%。这些结果表明维生素D及其代谢产物是雄性大鼠正常生殖功能所必需的。
The effect of vitamin D deficiency on the fertility and reproductive capacity of male rats was investigated. Male weanling rats were fed vitamin D-deficient or vitamin D-replete diets until maturity, and mated to age-matched, vitamin D-replete females. Vitamin D-deficient males were capable of reproduction. However, successful matings, i.e., presence of sperm in the vaginal tract of the female, by vitamin D-deficient males were reduced by 45% when compared to matings by vitamin D-replete males. Fertility (successful pregnancies in sperm-positive females) was reduced by 73% in litters from vitamin D-deficient male inseminations when compared to litters from females inseminated by vitamin D-replete males. These results demonstrate that vitamin D and its metabolites are necessary for normal reproductive functions in the male rat.