Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [18F]FDG-PET of Rats
Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [18F]FDG-PET of Rats
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DOI：
10.1007/s11307-018-1182-2
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Hongkai Wang;Ziyu Tan;Q. Zheng;Jing Yu
中科院分区：
文献类型：
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作者：
Hongkai Wang;Ziyu Tan;Q. Zheng;Jing Yu
目的近年来的研究表明，应用2-脱氧-2-[18 F]氟代-D-葡萄糖（[18 F]FDG）正电子发射断层扫描（PET）显像技术，对甲状腺功能减退相关的局部脑损害进行研究具有重要价值。然而，甲状腺功能减退对整个大脑网络的影响几乎没有研究。本研究应用图论方法分析甲减症状的脑功能网络，方法对甲减组和对照组Wistar大鼠58个脑区的糖代谢相关矩阵进行阈值化处理，构建甲减症状脑功能网络。网络的拓扑性质（包括小世界属性和节点的中心性）进行了计算和比较，两个groups.ResultsWe发现，大鼠的大脑，像人类的大脑，具有典型的小世界网络的属性在甲状腺功能减退症和对照组。然而，甲状腺功能减退症组表现出较低的整体效率和减少局部小集团的大脑网络，表明甲状腺功能减退症相关的损害的大脑网络。甲状腺功能减退组在左侧后海马、右侧下丘脑、垂体、脑桥和延髓中的淋巴结中心性也降低。这一观察结果与甲状腺功能减退相关的功能障碍的下丘脑-垂体-甲状腺（HPT）反馈调节mechanism.ConclusionOur研究定量证实，甲状腺功能减退症阻碍大脑认知功能，造成损害的大脑网络的葡萄糖代谢。本研究揭示了图论方法应用于临床前[18 F]FDG-PET图像的可行性和有效性，为将来在人体上的研究提供了便利。
PurposeRecent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study focuses on the application of graph theory on analyzing functional brain networks of the hypothyroidism symptom.ProceduresFor both the hypothyroidism and the control groups of Wistar rats, the functional brain networks were constructed by thresholding the glucose metabolism correlation matrices of 58 brain regions. The network topological properties (including the small-world properties and the nodal centralities) were calculated and compared between the two groups.ResultsWe found that the rat brains, like human brains, have typical properties of the small-world network in both the hypothyroidism and the control groups. However, the hypothyroidism group demonstrated lower global efficiency and decreased local cliquishness of the brain network, indicating hypothyroidism-related impairment to the brain network. The hypothyroidism group also has decreased nodal centrality in the left posterior hippocampus, the right hypothalamus, pituitary, pons, and medulla. This observation accorded with the hypothyroidism-related functional disorder of hypothalamus-pituitary-thyroid (HPT) feedback regulation mechanism.ConclusionOur research quantitatively confirms that hypothyroidism hampers brain cognitive function by causing impairment to the brain network of glucose metabolism. This study reveals the feasibility and validity of applying graph theory method to preclinical [18F]FDG-PET images and facilitates future study on human subjects.