Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients
Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients
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HLA-DQw3 (TA10−) 与 I 型糖尿病的关联出现在 DR3/4 患者中，但在 DR1/4 患者中则不然
DOI：
10.2337/diab.37.7.926
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发表时间：
1988
期刊：
影响因子：
7.7
通讯作者：
L. Harrison
中科院分区：
文献类型：
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作者：
B. Tait;G. Mraz;L. Harrison
我们在以前的研究中已经表明，HLA-DQw 3的TA 10 −亚型在HLA-DR 4 I型（胰岛素依赖型）糖尿病患者中显著增加。本文中的数据表明，这种关联仅发生在杂合子DR 3/4患者中，而不是DR 1/4患者中。由于在I型糖尿病中存在DR 3/4和DR 1/4的交互作用，数据表明DR 4单倍型的贡献取决于同源染色体上携带的单倍型。此外，与DR 1/4或DR 4/X（具有不同DR等位基因的患者的合并组）相比，DR 3/4的DQw 3（TA 10 −）糖尿病受试者中B44-DR 4单倍型的频率降低。这一发现表明，B44-DR 4单倍型在I型糖尿病中的减少不仅依赖于其与DQw 3（TA 10 −）等位基因的连锁不平衡，而且还表明存在独立发挥的额外效应。
We have shown in previous studies that the TA10− subtype of HLA-DQw3 is significantly increased in HLA-DR4 type I (insulin-dependent) diabetic patients. Data presented in this article indicate that this association only occurs in heterozygous DR3/4 patients and not in DR1/4 patients. Because there is an interactive effect of both DR3/4 and DR1/4 in type I diabetes, the data indicate that the contribution of DR4 haplotypes varies depending on the haplotype borne on the homologous chromosome. In addition, the frequency of the B44-DR4 haplotype was shown to be decreased in DQw3 (TA10−) diabetic subjects who were DR3/4 compared with those who were DR1/4 or DR4/X (a pooled group of patients with different DR alleles). This finding suggests that the decrease in the B44-DR4 haplotype in type I diabetes is not solely dependent on its linkage disequilibrium with the DQw3 (TA10−) allele but suggests there is an additional effect exerted independently.